Wyeth

Biqi Wu

Diane H Boschelli

Nan Zhang

Dan Maarten Berger

Dennis William Powell

Allan Wissner

Hwei-Ru Tsou

Fei Ye

Frenel Fils DeMorin

Yanong Daniel Wang

Minu D Dutia

Ayako Yamashita

Elsebe Geraldine Overbeek-Klumpers

Frank Boschelli

Haris Durutlic

Ana Carolina Barrios Sosa

Derek Cecil Cole

Russell Dushin

Lawrence Nathan Tumey

Magda Asselin

Amarnauth Shastrie Prashad

Jay Thomas Afragola

Diane Marie Joseph-McCarthy

Asaf Ragim Alimardanov

Chuan S Niu

Joan Chen

Diane Harris Boschelli

Diane Marie Joseph-Mccarthy

Diane Marie Joseph-Mcarthy

The present teachings provide compounds of formula I and their pharmaceutically acceptable salts, hydrates, and esters, wherein R, R, and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.

Substituted 3-cyanopyridines as protein kinase inhibitors

This invention provides a compound of Formula 1 where Ar, X, R, R, R, and Rare defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition of diseases associated with the Ras/Raf/MEK signaling cascade in a mammal, such as neoplasms, strokes, osteoporosis, cancer, rheumatoid arthritis, inflammatory disease, polycystic kidney disease, and colonic polyps, and methods of making the compounds of formula 1 and intermediates.

3-Quinolinecarbonitrile protein kinase inhibitors

This invention relates to compounds having the structure of Formula I wherein R, R, R, and Rare described herein.

4-(2,4-dichloro-5-methoxyphenyl)amino-6-methoxy-7-{[5-substituted-amino)methyl]-3-furyl}-3-quinolinecarbonitriles as kinase inhibitors

This invention provides compounds of Formula (1)&#x2013;(1), II wherein:

Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors

This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.

Tricyclic protein kinase inhibitors

This invention provides compounds of Formula (1a)-(1f)wherein:

3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors

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Nanuet, NY, United States of America

Biqi Wu