University of Texas System

Bipulendu Jena

Laurence J N Cooper

Laurence Jn Cooper

Sourindra Maiti

Antibodies and antigen binding fragments thereof are provided that bind to T-cell receptors (e.g., TCR&#x3b1;), essentially independent of T-cell epitope specificity. Methods for manipulation of T-cells and methods of treatment using such antibodies are likewise provided.

T-cell receptor (TCR)-binding antibodies and uses thereof

Chimeric antigen receptor (CAR) constructs are provided that are able to selectively bind to specific protein complexes, such as HER 1/HER3 heterodimer receptors. CAR T-cells comprising these constructs can be used to safely and efficiently target cancer cells expressing specific protein complexes.

Chimeric antigen receptors (CAR) to selectively target protein complexes

Provided are monoclonal antibodies that detect CD 19 CAR-modified immune cells and CAR-modified immune cells irrespective of the tumor associated antigen they target. Methods of using these functional monoclonal antibodies include, but are not limited to, detection, quantification, activation, and selective propagation of CAR-modified immune cells.

Growing community of inventors

Houston, TX, United States of America

Bipulendu Jena