Genentech, Inc.

BinQuing Wei

Alan G Olivero

Robert Andrew Heald

Chudi Obioma Ndubaku

Timothy Heffron

Graham Elgin Jones

Lan Wang

Jennafer Dotson

Neville James McLean

Laurent Salphati

Sussie Lerche Krintel

Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions.  Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described.

Tricyclic PI3K inhibitor compounds and methods of use

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Belmont, CA, United States of America

BinQuing Wei