Hangzhou Minsheng Pharmaceutical Co. Ltd

Hangzhou Yuanchang Medical Sci-tech Co., Ltd

Hangzhou Minsheng Institutes for Pharma Research Co., Ltd

Hangzhou Minsheng Institutes for Pharma Research

Hangzhou Minsheng Pharmaceuticals Co., Ltd.

Binnan Huang

Ximing Shen

Dianwu Guo

Shulong Wang

Yaodong Wu

Lan Yang

Feiyu Feng

Qiufu Ge

Chunxia Wu

Zhenhua Liu

Zhonghua Peng

Jiaqi Shan

Jian Cai

The invention provides gemcitabine derivatives shown in the following formula (I) and preparation methods thereof. The invention further relates to a pharmaceutical composition which comprising the said gemcitabine derivatives in an effective amount and a pharmaceutically acceptable excipient or additive. The invention further provides use of the said derivatives for preparing anti-tumor drugs. The compound designed by the invention is novel in structure and has a remarkable anti-tumor activity. According to the compound designed by the invention, the preparation starting materials have extensive sources and are easily obtained, the preparation method is simple and easy to operate, and the yield of the product is high, so that industrial production on a large scale is facilitated. 

Gemcitabine derivatives, compositions comprising same and pharmaceutical applications thereof

A class of quinazoline derivatives or pharmaceutically acceptable salts or solvates thereof with novel structures is provided; meanwhile, a pharmaceutical composition comprising a pharmaceutically effective amount of said quinazoline derivatives or pharmaceutically acceptable salts or solvates thereof, and pharmaceutically acceptable excipients or additives is also provided. By modifying and transforming the quinazoline and screening of the transformed compounds on the activity of tyrosine kinase inhibition, most of the compounds have been found to possess inhibitory activity against one or several of EGFR, VEGFR-2, c-erbB-2, c-erbB-4, c-met, tie-2, PDGFR, c-src, lck, Zap70 and fyn kinases. The present invention has the advantages of reasonable design, broad source of and easy access to the raw materials, simple and easy operation of the preparation methods, mild reaction conditions, high yield of the products and being beneficial for industrial-scale production.

Quinazoline derivative, composition having the derivative, and use of the derivative in preparing medicament

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Zhejiang, China

Binnan Huang