The City University of New York

Binlin Wu

Robert R Alfano

Lingyan Shi

Swapan Kumar Gayen

Wei Cai

A Compact Optical Virus Detection Analyzer (COVDA) uses light scattering and fluorescence to detect nanometer (nm) and micrometer (um) sized particles, such as biological particles and can be used to detect viruses such as coronavirus including SAR-CoV-2 responsible for COVID-19, pollen and bacteria. It can be used for prescreening, rapid detection of suspicious people. COVDA involves experimental and theoretical methods for particle and virus detection using Tryptophan as a key biomarker. Light sources in compact units include lamps such as Xenon (Xe) lamp with narrow band filters, LEDs (such as AlN) or laser diode, Q switched and mode lock Lasers for nanosecond and picosecond pulses (such as Nd Yag/Glass, Ti sapphire with Harmonic generator) in blue from 400 nm to 500 nm to generate second harmonic generation (SHG) in KDP/BBO crystals to produce 200 nm to 250 nm emission, or green laser pointers at about 530 nm to get emitters with harmonic crystals at about 270 nm or LEDS from 230 nm to 300 nm for pumping the samples at 230 nm to 289 nm to pump tryptophan and light scatter of nanometer particles of virus. The ultra high power ns and ps lasers in mJ to J can level can be used to locate Bio virus bacteria clouds in free space to image and destroy and kill virus.

Compact optical virus detection analyzer of nano- and micro-size bio particles using light scattering and fluorescence

A time reversal optical tomography (TROT) method for near-infrared (NM) diffuse optical imaging of targets embedded in a highly scattering turbid medium is presented. TROT combines the basic symmetry of time reversal invariance and subspace-based signal processing for retrieval of target location. The efficacy of TROT is tested using simulated data and data obtained from NIR imaging experiments on absorptive, scattering and fluorescent targets embedded in Intralipid-20% suspension in water, as turbid medium, as well as, a realistic cancerous model breast assembled using ex vivo human breast tissues with two embedded tumors. The results demonstrate the potential of TROT for detecting and locating small targets in a turbid medium, such as, breast tumors in early stages of growth.

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Forest Hills, NY, United States of America

Binlin Wu