Affiliated Eye Institute of Shandong First Medical University

Institute of Ophthalmology Affiliated to Shandong First Medical University (Shandong Institute of Ophthalmo

Bining Zhang

Qingjun Zhou

Qing Liu

Weiyun Shi

Hongwei Wang

Wenfeng Li

Zhichao Ren

Yusen Huang

Huabo Chen

In view of the problem that the current prevention and treatment manners for corneal neovascularization (CNV) may cause complications, the present disclosure provides an application of CB-839 in preparation of a drug for inhibiting CNV. The CB-839-loaded drug of the present disclosure can significantly inhibit CNV in mice and reduce the infiltration of inflammatory cells without obvious side effects, which makes up for the shortcoming of the prior art.

Application of CB-839 in preparation of drug for inhibiting corneal neovascularization (CNV)

Disclosed are probes, primers, a microarray, a kit and applications for rapid detection of clinical microorganism in ophthalmology, belonging to that technical field of clinical microorganism detection. The probes of that disclosure comprise probes for respectively detectand. The disclosure also discloses primers for amplifying the target bacteria, which comprises primers which can amplify gene sequence fragments with intra-species homology of more than 95 percent (%) and inter-species homology of less than 75%. The disclosure also provides a method for synthesizing the hybridization probe on the microarray, a method for hybridization reaction and a method for scanning detection. The probes described in the present invention are highly specific and detects microorganisms in ophthalmic clinical samples with sufficient positivity, high accuracy and deliver diagnosis in a short period of time.

Probes, microarray, primers, kit and applications for rapid detection of clinical ophthalmic microorganisms

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Qingdao, China

Bining Zhang