General Incorporated Association Tsukuba Global Innovation Promotion Agency

Crestecbio Inc.

University of Tsukuba

Binh Long Vong

Yukio Nagasaki

Quoc Thang Bui

Yuji Hiramatsu

Shinpei Kudo

Takuya Inagaki

Hiroaki Sakamoto

A copolymer which includes hydrophilic and hydrophobic blocks, which can form nanoparticles in which a physiologically active substance can be efficiently packaged therein and which are stable under acidic conditions. The hydrophilic segment of the copolymer is composed of polyethylene glycol (PEG) and the hydrophobic segment is composed of polystyrene. The hydrophobic segment has a side chain, and the side chain has ends to which a cyclic nitroxide radical having a radical scavenging function and a trialkoxysilane are covalently bonded.

Copolymer containing cyclic nitroxide radical and trialkoxysilyl in side chain, and use thereof

An object of the present invention is to provide a composition that serves as an efficient arginine substrate for inducible NO synthase (iNOS) in tumor. The present invention provides a polyion complex (PIC) of PEG-b-poly(L-Arg) or poly(L-Arg)-b-PEG-b-poly(L-Arg) and a polyanionic polymer, and use thereof.

Polyion complex of poly(L-arginine) segment-containing block copolymer and polyanionic polymer

Growing community of inventors

Ibaraki, Japan

Binh Long Vong