Institute of Radiation Medicine, Academy of Military Medical Sciences, Pla.

Bingxing Shi

Zuze Wu

Aiping Yu

Chunping Cui

Danli Wu

Shaojun Du

Chunna Dong

Provided are a hepatopoietin PCn (HPPCn) and its homologous proteins, which can promote hepatocyte proliferation in vitro, promote liver regeneration in vivo, inhibit the growth of tumor cells and promote the apoptosis of tumor cells. The hepatopoietin PCn (HPPCn) and its homologous proteins are useful for the treatment of acute and chronic liver injury, or the treatment of liver fibrosis.

Hepatopoietin and use thereof

This application relates to a fusion protein, which is composed of a thrombolytic protein, an anticoagulant protein, and a linker peptide. In particular, the fusion protein is composed of an anticoagulant protein and a protein molecule having plasminogen-activating activity, wherein said two proteins are linked together via a linker peptide, which can be recognized and cleaved by blood coagulation factors. The application also relates to the medical use of said fusion protein, and to the use of the linker peptide which can be recognized by blood coagulation factor in linking a thrombolytic protein and an anticoagulation protein.

Bifunctional fusion protein with thrombolytic and anticoagulant activities and uses thereof

Growing community of inventors

Beijing, China

Bingxing Shi