Velicept Therapeutics, Inc.

Neuralstem, Inc.

B3ar Therapeutics, Inc.

Takeda Pharmaceutical Company Limited

Qaam Pharmaceuticals, LLC

Bingidimi Itute Mobele

Dalian Zhao

Raymond E Stevens

Sripathy Venkatraman

Ying Li

Olga V Lapina

Mark McLaws

Syed Mahmood

Kellie Vercoe

Jonathan Salsbury

Jeffrey Alan Stafford

Jun Feng

Stephen L Gwaltney

Zhiyuan Zhang

Paul Isbester

Grant Jackson Palmer

Satish Puppali

Steven A Rich

Bruce Joseph Elder

Luckner Gerard Ulysse

Jonathon Stuart Salsbury

Richard S Fornicola

Emerich Eisenreich

Xuejun Karl Liu

Maxwell M Reeve

Paul R Brodfuahrer

Philip B Kisanga

This application relates to solabegron zwitterion useful for the treatment of lower urinary tract symptoms such as, for example, overactive bladder and prostate disorders. Additionally, this application relates to pharmaceutical compositions and methods of treatment utilizing the solabegron zwitterion for treating lower urinary tract symptoms. This application also relates to methods of preparing solabegron hydrochloride from the solabegron zwitterion.

Solabegron zwitterion and uses thereof

Novel glycopyrronium fatty acid salts have been developed. Bi-phasic reaction conditions enable the desired counterion exchange reactions between glycopyrronium bromide and fatty acid salts of alkali metals and alkaline earth metals in methods to form glycopyrronium fatty acid salts. In preferred embodiments, an excess of the free fatty acid in the reaction mixture stabilizes the glycopyrronium fatty acid salt and reduces the formation of the impurity, Acid A. In some preferred embodiments, between 0.2 and 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture. In another embodiment, approximately 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture.

Glycopyrronium fatty acid salts and methods of making same

The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions.

Synthesis of a neurostimulative piperazine

Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase. 

Dipeptidyl peptidase inhibitors

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Bingidimi Itute Mobele