Cibt America Inc.

Cathay Biotech Inc.

Cathay Industrial Biotech Ltd.

Cathay R&d Center Co., Ltd

Cathay (jinxiang) Biomaterial Co., Ltd.

Shanxi Synthetic Biology Institute Co., Ltd.

Bingbing Qin

Xiucai Liu

Naiqiang Li

Charlie Liu

Chen Yang

Yufeng Yang

Kai Wang

Yang Chen

Xiaoming Li

Yi Zheng

Shanshi Guo

Benliang Hou

Duanfang Dai

Min Xu

Chi Liu

Guang Lei

Yuanbo Zhao

Xiwei Yang

Huiqing Zang

Xuicai Liu

The present invention provides a process for producing a high temperature resistant polyamide, the high temperature resistant polyamide and the use thereof. The process comprises: optionally concentrating a polyamide salt solution, and then conducting the following operations: heating and pressurizing to a pressure of P1, and maintaining the pressure, wherein the temperature of the system is T1 at the end of the pressure-maintenance; depressurizing to a pressure of P2, wherein the temperature of the system is T2 at the end of the depressurization; and evacuating, whereby a polyamide melt is obtained; wherein P1 is 0.8-4 MPa, T1 is 250-290° C., T1<T2 and (T2−T1)/(P1−P2)=5-75. The process for producing a high temperature resistant polyamide according to the present invention is simple to operate and reduces energy consumption. The obtained high temperature resistant polyamide may be used as a raw material for such injection molded parts, molded articles, or fibers as high temperature resistant attachments for machines, automobiles, household appliances, toys, textiles, sporting goods, mobile phones, computers, laptops, GPS devices, or optical devices.

Method for producing high temperature-resistant polyamide, high temperature-resistant polyamide and use thereof

The present disclosure provides methods for isolating a long chain dicarboxylic acid such as a substantially pure or pure long chain dicarboxylic acid from a fermentation broth containing microbial cells.

Solid-solid separation process for long chain dicarboxylic acids

The present disclosure provides a system for refining long chain dicarboxylic acid, comprising: a first membrane filtration unit, for a first membrane filtration of a long chain dicarboxylic acid fermentation broth or a treated liquid therefrom; a first decolorization unit, for carrying out a first decolorization treatment to the filtrate obtained after the membrane filtration; a first acidification/crystallization unit, for carrying out a first acidification/crystallization of a filtrate obtained after the membrane filtration to give a solid-liquid mixture; a first separation unit, for a solid-liquid separation of the solid-liquid mixture; a drying unit, for drying the solid separated by the separation unit to give a first solid. By using the refining system according to the present disclosure, the purity of the obtained product is high, and the disadvantages such as poor quality of the product obtained by crystallization from a solvent and environment pollution caused by a solvent can be overcome.

Method and system for refining long chain dicarboxylic acid

The present disclosure provides method for isolating a long chain dicarboxylic acid such as a substantially pure or pure long chain dicarboxylic acid from a fermentation broth containing microbial cells.

The present invention discloses a method for producing a long chain dicarboxylic acid by fermentation as well as a fermentation broth, a treated fermentation broth and a wastewater. The salt content in the fermentation broth is controlled to be below 20% by the fermentation method of the present invention. The method for producing a long chain dicarboxylic acid by fermentation provided by the present invention can effectively reduce the amount of alkali used in the fermentation process and the amount of acid used in the subsequent extraction of the long chain dicarboxylic acid, thereby reducing the amount of salt in the whole production process of the long chain dicarboxylic acid. At the same time, the method of the present invention also has many advantages such as shortening the fermentation time, increasing the acid production, reducing the amount of medium, and suitable for the production of various types of long-chain dicarboxylic acids, etc. Compared with the existing production process, the method of the present invention not only has significant cost advantages, but also can effectively reduce the pressure on resource and environment, thus it has a very obvious value advantage in industrialization.

Method for producing a long chain dicarboxylic acid by fermentation, fermentation broth, treated fermentation broth and wastewater

The present disclosure provides a method and a system for refining long chain dicarboxylic acid, said method comprising the following steps: (1) subjecting a long chain dicarboxylic acid fermentation broth or a treated liquid therefrom to a membrane filtration, an acidification/crystallization, a solid-liquid separation and drying to give a long chain dicarboxylic acid crude product; (2) subjecting the long chain dicarboxylic acid crude product to a vacuum distillation to give the long chain dicarboxylic acid product; wherein the pressure in the vacuum distillation is &#x2264;100 Pa. By using the refining method according to the present disclosure, the procedure is simplified, and the purity of the obtained product is high, and the disadvantages such as poor quality of the product obtained by crystallization from a solvent and environment pollution caused by a solvent can be overcome.

Provided is a method for purifying 1,5-pentanediamine comprising: providing 1,5-pentanediamine to be purified and treating the 1,5-pentanediamine to be purified by a reduction reaction to obtain purified 1,5-pentanediamine. Meanwhile, further provided is 1,5-pentanediamine prepared by the method. The purification method has a concise process and a simple operation, and is suitable for industrial production, and can significantly improve the quality of 1,5-pentanediamine.

Method for purifying 1,5-pentanediamine and the 1,5-pentanediamine prepared thereby

The present disclosure provides a method for isolating a long chain dicarboxylic acid from fermentation broth containing microbial cells. Also provided is a substantially pure long chain dicarboxylic acid isolated by the method.

Provided is a method for extracting a 1,5-pentanediamine from a solution system containing a 1,5-pentanediamine salt. The method comprises adding to the solution system an insoluble basic substance to form a solution system containing free 1,5-pentanediamine. The provided method has high applicability, is easy to use, and is environmentally-friendly, significantly lowering raw material costs and operating costs for the entire manufacturing process. The method achieves a high recovery rate for pentanediamine, and is more suitable for industrial-scale production.

Method for extracting 1,5-pentanediamine from solution system containing 1,5-pentanediamine salt

Method for purifying 1,5-pentanediamine and 1,5-pentanediamine

The present invention provides a method for preparing nylon salt, which comprises mixing 1,5-pentanediamine, water and dicarboxylic acid at a temperature of 65 to 120&#xb0; C. to obtain a nylon salt, wherein the amount of the water is 2% to 12% by weight based on the total weight of the 1,5-pentanediamine and the dicarboxylic acid. The present invention also provides a nylon salt. According to the present method for preparing nylon salt, the incomplete reaction between the 1,5-pentanediamine and the dicarboxylic acid, which is caused by the nylon salt present during the preparation in a solid state, can be avoided; the reaction between the 1,5-pentanediamine and the dicarboxylic acid can be significantly speeded up, and the reaction time is accordingly shorten. Consequently, the content of diamine and dicarboxylic acid remained in the resulting nylon salt is very low. In addition, the final nylon salt product, which present in a solid state, makes it easier to be stored and transported.

Nylon salt and preparation method therefor

The present invention relates to a method for the purification of cadaverine from an aqueous cadaverine salt composition comprising one or more involatile impurities, the method comprising: (1) mixing the aqueous cadaverine salt composition with one or more bases to provide an aqueous cadaverine composition having a pH of at least about 12; (2) distilling or evaporating the aqueous cadaverine composition to produce an aqueous cadaverine solution, wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation stops, and the one or more solvents comprise at least one or more high boiling point (HBP) solvents having a boiling point of at least 185&#xb0; C. (1 atm); and (3) subjecting the aqueous cadaverine solution to one or more rectification steps to provide a cadaverine product.

Purification of cadaverine using high boiling point solvent

The invention relates to a method for preparing cadaverine comprising: (1) obtaining an aqueous cadaverine salt composition from a fermentation system; (2) adjusting the pH of the aqueous cadaverine salt composition to a pH of at least about 12 by adding an inorganic base composition to provide a first composition comprising an aqueous cadaverine composition having a pH of at least about 12 and a solid composition comprising one or more alkali metal sulfates; (3) subjecting the first composition to solid-liquid separation without organic solvent extraction to provide the aqueous cadaverine composition and the solid composition; (4) distilling or evaporating the aqueous cadaverine composition of step (3) without organic solvent extraction to provide purified cadaverine; (5) preparing a saturated solution of the alkali metal sulfate(s) from the solid composition of step (3) at a temperature of about 35-40&#xb0; C., mixing the saturated solution with NHHCO, and subjecting the mixture to solid-liquid separation to provide Solution (I) and Solid (I); (6) adjusting the temperature of Solution (I) to about 60-80&#xb0; C., and obtaining Solution (II) and Solid (II) after solid-liquid separation; (7) concentrating Solution (II) and obtaining Solution (III) and Solid (III) after solid-liquid separation; and (8) adding Solid (III) back to the fermentation system of step (1); wherein steps (1) to (8) are optionally repeated one or more times.

Preparation of cadaverine

The present invention relates to a method for the purification of cadaverine from an aqueous cadaverine salt composition comprising one or more involatile impurities, the method comprising: (1) mixing the aqueous cadaverine salt composition with one or more bases selected from the group consisting of Ca(OH), Mg(OH), CaO and MgO to provide an aqueous cadaverine composition; and (2) distilling or evaporating the aqueous cadaverine composition to produce purified cadaverine; wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation stops, and the one or more solvents comprise at least one or more high boiling point (HBP) solvents.

One aspect of the invention relates to a method for the purification of cadaverine from an aqueous cadaverine composition comprising one or more involatile impurities, the method comprising: a) distilling or evaporating the aqueous cadaverine composition wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation starts, during the evaporation/distillation and/or after the evaporation/distillation substantially stops when no more evaporation/distillation is observed to produce purified cadaverine, wherein the evaporation or distillation is done at a heating temperature of about 80&#xb0; C. to about 180&#xb0; C. and under a pressure of 1 atm or lower, and the one or more solvents comprise at least one or more high boiling point (HBP) solvents having a boiling point of at least about 185&#xb0; C. (1 atm); and b) recovering the one or more HBP solvents.

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Shanghai, China

Bingbing Qin