Bristol-Myers Squibb Compnay

Institute of Organic Chemistry and Biochemistry

Rega Stichting, V.z.w.

John C. Martin

Choung U. Kim

Bing Y. Luh

Peter F. Misco

Bing Y Luh

Peter F Misco

Choung U Kim

Joanne J Bronson

Yasutsugu Ueda

John C Martin

Stanley V D'Andrea

John D Matiskella

Dane M Springer

John A Wichtowski

Shelley E Hoeft

Novel cephem derivatives represented by the general formula ##STR1## in which the Acyl substituent is a group of the formula ##STR2## wherein Ar is a lipophilic optionally substituted phenyl, naphthyl or pyridyl group; R.sup.1 represents either the residue of a heterocyclic amino acid or a C.sub.2 -C.sub.10 alkyl group substituted by both a carboxyl group and a group of the formula --NR.sup.9 R.sup.10 or ##STR3## in which R.sup.9 and R.sup.10 are each independently hydrogen or C.sub.1 -C.sub.6 alkyl, said C.sub.2 -C.sub.10 alkyl group being optionally interrupted by one or more nitrogen atoms or carbonyl groups, and R.sup.2 and R.sup.3 are each independently hydrogen, alkyl or aminoalkyl are gram-positive antibacterial agents, especially useful in the treatment of diseases caused by methicillin-resistant Staphylococcus aureus (also referred to below as MRSA or methicillin-resistant S. aureus).

Substituted 4-thio pyridones

Cephalosporin derviatives

The present invention concerns nucleotide analogs and their compositions and use. In particular it relates to novel (phosphonomethoxy) methoxy purine/pyrimidine derivatives.

Antiviral (phosphonomethoxy)methoxy purine/pyrimidine derivatives

Thymidine kinase inhibitor of formula I ##STR1## in which R is C.sub.1-6 alkyl or AR(CH.sub.2).sub.n --, wherein Ar represents phenyl optionally substituted with one to five same or different halogen, C.sub.1-6 alkyl or C.sub.1-6 alkyloxy; and n equals one to six. A further aspect of the present invention provides a method of inhibiting viral thymidine kinase. Yet another aspect of the invention relates to treating herpes simplex viral infections in mammals. Yet another aspect of the invention provides a pharmaceutical formulation.

Thymidine derivatives and therapeutic method of use

Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives

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Killingworth, CT, United States of America

Bing Y Luh