Institute of Organic Chemistry and Biochemistry of the Academy of

Rega Stichting, V.z.w.

Bing Uh Luh

Choung U Kim

John C Martin

Peter F Misco

Provided are compounds of the following formulae:

Nucleoside analogs

Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or alkanoyl and

Vinyl ethers of nucleoside analogs

Phosphonate nucleoside analogs

Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or alkanoyl; B is a purine or pyrimidine base. optionally R is taken together with X' to complete a cyclic phosphonate having the formula ##STR2## A 4'-phosphonomethoxytetrahydrofuranyl-1'-purine-pyrimidine of the formula ##STR3## wherein X and X' are the same or different and are hydrogen or alkyl, the dashed line is an optional bond, Y and Z are the same or different and are hydrogen, hydroxyl or alkyl or Y+Z are taken together to form an epoxide or cyclopropyl, and B is a purine or pyrimidine base.

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Killingworth, CT, United States of America

Bing Uh Luh