Jiangsu Hengrui Medicine Company Ltd.

Nanjing University

Bing Liu

Xiaohui Gao

Yi Shi

Rong Zhang

Peng Chen

Tao Tao

Junlei Jia

Xiangqian Xiu

Lin Bian

Ting Zhi

Yi Li

Ping Han

Youdou Zheng

Zhili Xie

Zhiguo Yu

The present invention relates to a method for preparing a pyrimidone heteroaryl derivative and an intermediate of the pyrimidone heteroaryl derivative. Specifically, the pyrimidone heteroaryl derivative of the formula 

Method for preparing pyrimidone heteroaryl derivative and intermediate of pyrimidone heteroaryl derivative

Disclosed are an intermediate of a pyrrolo six-membered heteroaromatic ring derivative as a JAK inhibitor and a preparation method therefor, and a method for preparing a pyrrolo six-membered heteroaromatic ring derivative using the intermediate. The method improves the reaction yield, is simple and easy to operate and control, and is conducive to expanded industrial production.

Preparation method for and intermediate of pyrrolo six-membered heteroaromatic ring derivative

The present invention provides a method for removing burrs of battery electrode plates using inductively coupled plasma (ICP) dry etching, in which an induction coil is used for ionizing reaction gas. A DC bias is applied to accelerate the ionized reaction gas to bombard the burrs of electrode plate, removing burrs that formed in machining processes using physical bombardment. The equipment used in the present invention is an ICP etch system. The method according to the present invention can completely remove the burrs of electrode plate, thereby effectively preventing short circuits caused by burrs penetrating the membrane separator in the battery.

Method for removing burrs of battery electrode plates by inductively coupled plasma dry etching

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Jiangsu, China

Bing Liu