The University of Texas System

Binata Joddar

Thomas Boland

Katja Michael

David A Roberson

Philip T Baily

Hector P Del Castillo

Alfredo Ornelas Sanchez

Zayra N Dorado

Naveen Nagiah

Chunqlang Li

Javier Hernandez Ortega

Ivana Hernandez

Irodiel Vinales Lozano

Cardiac tissue-on-a-chip platforms aimed at mimicking human cardiac tissue structures, are valuable tools to model, and serve as preclinical platforms for drug testing or therapies for cardiac repair. We have developed three types of electrospun scaffolds including furfuryl gelatin (f-gelatin) alone, with polycaprolactone (PCL) in the ratio of f-gelatin and PCL (1:1), and coaxial scaffolds with PCL (core) and f-gelatin (sheath). Scaffolds were developed through single nozzle electrospinning and coaxial electrospinning, respectively, to serve as scaffolds for cardiac tissue-on-a-chip platforms.

Development and characterization of f-gelatin electrospun scaffolds for cardiac tissue modeling

Crosslinkers of an amide or thiocarbamate of 7-nitroindoline were prepared with at least two attached reactive groups for crosslinking capability. The photo-cleavability of the invented crosslinkers is based on the known photolysis behavior of N-acyl-7-nitroindolines, and the photolysis behavior of amides and thiocarbamates of 7-nitroindolines. These crosslinkers enable crosslinking of biopolymers, which can be reversed by illumination with light.

Photocleavable nitroindoline-based crosslinkers

Growing community of inventors

El Paso, TX, United States of America

Binata Joddar