Astrazeneca Ab

Bin Yang

Johannes Wilhelmus Maria Nissink

Bernard Barlaam

James Stewart Scott

Thomas Andrew Moss

Samantha Jayne Hughes

Daniel Hillebrand O'Donovan

Jeffrey Gilbert Varnes

Jason Grant Kettle

Dedong Wu

Bo Peng

Gillian McGregor Lamont

Jamal Carlos Saeh

Timothy Pontz

Brian Aquila

Timothy Gordon Rasmusson

Kumar Thakur

Victor Kamhi

Dan Anders Broo

Charlene Fallan

Thomas George Christopher Hayhow

Bernard Christophe Barlaam

The specification relates to compounds of Formula (I): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cell proliferative disorders.

Chemical compounds

Selective estrogen receptor down-regulators

The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts and prodrugs thereof, where R, R, R, R, R, Linker, X, Y, A, G, D and E have any of the meanings defined herein. This specification also relates to the use of such compounds and pharmaceutically acceptable salts and prodrugs thereof in methods of treatment of the human or animal body, for example in prevention or treatment of cancer. This specification also relates to processes and intermediate compounds involved in the preparation of such compounds and to pharmaceutical compositions containing them.

Compounds and their use in treating cancer

The specification relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

The specification relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

The present invention relates to compounds of Formula (I) and/or Formula (Ia): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit ALK kinase activity, and thus may be used for the treatment of cancer.

Growing community of inventors

Waltham, MA, United States of America

Bin Yang