Case Western Reserve University

Cleveland State University

Bin Su

Monica M Montano

Aimin Zhou

Bingcheng Wang

Yan Xu

Aaron Petty

A method of treating cancer in a subject includes administering to the subject a therapeutically effective amount of a compound, the small molecule having a general formula: A-L-X—Z (I).

Peptide and small molecule agonists of EphA and their uses

A method of inducing HEXIM1 expression in cells of a subject includes administering to the cells a compound having the formula, and pharmaceutically acceptable salts thereof.

Compositions and methods for modulating HEXIM1 expression

The potency of a series of Hexamethylene bis-acetamide (HMBA) derivatives of formula I, that induce Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) was determined in cancer cells. The method of inducing HEXIM1 expression and cell differentiation in cancer and HIV cells are disclosed. Optimization of HMBA analogs that are symmetrical and unsymmetrical are also discussed.

Compositions and methods for modulating HEXM1 expression

The invention provides a compound of formula (I), a pharmaceutical composition thereof, a method of preparing a medicament for the treatment of a cancer, and a method of treating cancers. The invention exhibits merits against cancers such as significantly higher potency and effectiveness over a broader range of cancers. In formula (I), Ris a benzyl group with alkyl and/or alkoxy; Ris selected from H and alkyl groups; Ris an alkyl; and Ris selected from a substituted phenyl, a heterocyclic group, and wherein Rc is selected from a fused ring, fused rings, and any bivalent cyclic group. 

Growing community of inventors

Cleveland, OH, United States of America

Bin Su