Washington University

Other

California Institute of Technology

Bin Rao

Lihong V Wang

Konstantin Maslov

Liang Song

Ruiying Zhang

A probe for use with an imaging system, including a scanning device configured to receive a first light beam from a light source, a beam-divider configured to split the first light beam into a plurality of second light beams, and a focusing device configured to focus each of the second light beams on respective locations in an object of interest is disclosed.

Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection

The present invention relates to a selective photothermolysis device comprising: a tunable radiation source configured to emit radiation; a patient interface comprising a radiation delivery unit configured to deliver the radiation to a tissue, and an ultrasonic detector for detecting photoacoustic waves excited by the radiation from one or more surgical targets in the tissue; and a control system configured to acquire characteristics of the tissue and one or more surgical targets based on measurements on detected photoacoustic waves, determine optimal characteristics of the tunable radiation source for optimal surgical outcome on one or more surgical targets in the tissue, prescribe characteristics and optimal characteristics, and adjust the tunable radiation source for optimal surgical outcome based on the optimal characteristics, and methods applicable to the device.

Methods and apparatus for optimizing selective photothermolysis

A laser with a wide continuous wavelength tuning range is desirable for optimized selective photothermolysis (SP) laser surgeries that treat light-absorptive lesions and unwanted pigments in human tissue with minimal collateral damages. However, current SP laser surgical systems are limited to a few lasing lines including 1064 nm by Nd:YAG, 755 nm by Alexandrite, 694 nm by Ruby, and 532 nm by second harmonic generation of 1064 nm. This invention discloses techniques to implement a high power, tunable optical parametric oscillator (OPO) system for demanding SP applications such as laser tattoo removal. In addition to wavelength tuning, the OPO laser system's output pulse energy, pulse duration, and pulse-train duration are also adjustable by tuning the pump laser pulse energy, pump laser pulse duration, and pump laser pulse-train duration for optimizing SP laser surgical outcomes.

High power tunable optical parametric oscillator for selective photothermolysis laser surgeries

A method for fast high-resolution deep photoacoustic tomography of action potentials in brains is provided herein. The method may utilize a high-speed, high-spatial-resolution, deep-penetration photoacoustic computed tomography (PACT) system for real-time imaging of action potentials.

Nonradiative voltage-sensitive dye for imaging neuronal action potential

A probe for use with an imaging system, including a scanning device configured to receive a first light beam from a light source, a beam-divider configured to split the first light beam into a plurality of second light beams, and a focusing device configured to focus each of the second light beams on respective locations in an object of interest.

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St. Louis, MO, United States of America

Bin Rao