Shandong University

Wanhua Chemical Group Co., Ltd.

Xuanzhu Biopharmaceutical Co., Ltd.

Wanhua Chemical (ningbo) Co., Ltd.

Shandong Shengquan New Materials Co., Ltd.

Shandong Xuanzhu Pharma Co., Ltd.

Jinan Jubang Information Technology Co., Ltd

Wanhua Chemical Co., Ltd.

Bin Liu

Shucai Li

Xinji Xu

Lichao Nie

Zhengyu Liu

Jie Song

Huaifeng Sun

Chuanwu Wang

Changxun Ju

Yang Liu

Chunjin Lin

Zhengfang Wang

Peng Jiang

Yuxiao Ren

Fuguo Li

Chengqun Qin

Lunpeng Wang

Yao Li

Lei Xu

Jing Wang

Qingmei Sui

Jing Li

Lei Chen

Hanchi Liu

Bing Zheng

Xunkun Wu

Fengkai Zhang

Xiangxue Ma

Tingyu Hao

Chao Fu

Weiqi Hua

Yuan Li

Hongtao Zhu

Bin Wang

Bo Chen

Lei Yang

Hanpeng Wang

Faye Zhang

Weimin Yang

Senlin Yang

Bo Zhang

Qingyang Wang

Ye Sun

Qian Guo

Diyuan Tang

Zhilin Tang

Wei Cui

Hao Song

Zhifang Li

Ke Bai

Chuanming Sun

Mingyong Wang

Tian Ye

Zhengyang Shi

Haidong Liu

Wenqiang Kang

Jiaqi Zhang

Duo Li

Naihua Jiang

Jiansen Wang

Lei Hao

Biao Li

Mengmeng Hu

Yan Zhu

Guangzu Zhao

Ruirui Wang

Boyang Gao

Xu Guo

Yaxu Wang

Hao Zhou

Yuqiang Cao

Shuangyi Sun

Jing Zhao

A blockchain-based big data analysis and decision-making system and method implement consolidation of a key mapping table preset by the system. On-chain storage of a blockchain can be adopted, thereby avoiding missing an association relationship of security policy query when performing decision-making in network security events. By taking a security event as a unit, network attack data can be separated at an appropriate granularity more reasonably by analyzing network security attack events and fault events and performing targeted decision-making based on event-based attack information, thereby implementing differentiated protection of network security and more accurate granularity of network security protection. Based on security attack big data in a cloud computing system, event-based security information big data can be migrated to a cloud to consolidate storage. The system can acquire relevant information of historical security events out of band to assist in performing blockchain-based event-based target intelligent big data analysis and decision-making.

Blockchain-based big data analysis and decision-making system and method

The present invention relates to the technical field of pharmaceuticals, and in particular to a ketohexokinase inhibitor compound, a pharmaceutically acceptable salt, an ester or a stereoisomer thereof, a pharmaceutical composition and formulation containing the compound, the pharmaceutically acceptable salt, the ester or the stereoisomer thereof; a method for preparing the compound, the pharmaceutically acceptable salt, the ester or the stereoisomer thereof; and use of the compound, the pharmaceutically acceptable salt, the ester or the stereoisomer thereof in the manufacture of a medicament for treating and/or preventing KHK-mediated diseases and related conditions.

Hexone glucokinase inhibitor and use thereof

The present invention belongs to the technical field of medicine, and relates to a macrocyclic tyrosine kinase inhibitor and the uses thereof. Specifically, the invention relates to a compound of general formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, a preparation method therefor, a pharmaceutical formulation or a pharmaceutical composition containing same, and medical uses thereof.

Macrocyclic tyrosine kinase inhibitor and uses thereof

Disclosed by the present invention is a method for preparing a reactive sealant resin, the method comprising: (1) under the action of an alkali catalyst, polymerizing a hydroxyl-containing initiator with an epoxy compound to obtain a polyether polyol; (2) adding an alkoxide reagent and a halogenated end-capping agent containing a double bond to the polyether polyol obtained in step (1) for reaction, so as to obtain a crude double-bonded polyether product, and refining the crude product to obtain a modified polyether product; and (3) subjecting the modified polyether and hydrogen-containing silane to silane end-capping reaction under the action of a hydrosilylation catalyst, so as to obtain the target product, i.e., a reactive sealant resin. The resin has excellent properties as well as good adhesion and paintability.

Method for preparing reactive sealant resin

A multi-arm robot used for tunnel lining inspection and defect diagnosis in an operation period, including a moving platform, where an environment detection device and a defect infection device are disposed on the moving platform, the defect infection device is disposed on the moving platform by using a multi-degree-of-freedom mechanical arm, and an attitude detection module is disposed on each multi-degree-of-freedom mechanical arm; a controller receives environmental data and mechanical arm attitude data sensed by the environment detection device and the attitude detection module, and sends a control instruction to the moving platform and the multi-degree-of-freedom mechanical arm according to the environmental data, to implement movement of the robot; and the controller receives tunnel lining structural data sensed by the defect infection device, and performs defect diagnosis. Overall automatic inspection can be implemented both on the surface and inside of the tunnel lining.

Multi-arm robot used for tunnel lining inspection and defect diagnosis in operation period

A multi-scale inspection and intelligent diagnosis system and method for tunnel structural defects includes: a traveling section; a supporting section, disposed on the traveling section, and including a rotatable telescopic platform, where two mechanical arms working in parallel are disposed on the rotatable telescopic platform; an inspection section, mounted on the supporting section, and configured to perform multi-scale inspection on surface defects and internal defects in different depth ranges of a same position of a tunnel structure, and transmit inspected defect information to a control section; and the control section, configured to: construct a deep neural network-based defect diagnosis model; construct a data set by using historical surface defect and internal defect information, and train the deep neural network-based defect diagnosis model; and receive multi-scale inspection information in real time, and automatically recognize types, positions, contours, and dielectric attributes of the internal and surface defects.

Multi-scale inspection and intelligent diagnosis system and method for tunnel structural defects

A stable dispersant and an application thereof in preparing copolymer polyols, the preparation method for the stable dispersant including the steps of 1) contacting a polyol with a dianhydride compound for reaction so as to prepare an adduct; 2) performing a ring-opening addition reaction on the adduct obtained in step 1) and an epoxy compound to prepare a stable dispersant; the dianhydride compound does not contain a double bond that may copolymerize with an olefinically unsaturated monomer, while the epoxy compound contains a double bond that may copolymerize with an olefinically unsaturated monomer, the polyol is a polyester polyol and/or a polyether polyol, preferably being a polyether polyol. The stable dispersant obtained by means of the described preparation method has a multi-active site anchoring function, and is applied to the synthesis of copolymer polyols to obtain copolymer polyols having relatively uniform particle size.

Stable dispersant and application thereof in preparing copolymer polyols

An adhesion promoter as shown in Formula (I) and a photosensitive resin composition containing the adhesion promoter are disclosed:

Adhesion promoter and photosensitive resin composition containing same

A multi-scale unsupervised seismic velocity inversion method based on an autoencoder for observation data. Large-scale information is extracted by the autoencoder, which is used for guiding an inversion network to complete the recovery of different-scale features in a velocity model, thereby reducing the non-linearity degree of inversion. A trained encoder part is embedded into the network to complete the extraction of seismic observation data information at the front end, so it can better analyze the information contained in seismic data, the mapping relationship between the data and velocity model is established better, then the inversion method is unsupervised, and location codes are added to the observation data to assist the network in perceiving the layout form of an observation system, which facilitates practical engineering application. Thus a relatively accurate inversion result of the seismic velocity model when no real geological model serves as a network training label can be achieved.

Multi-scale unsupervised seismic velocity inversion method based on autoencoder for observation data

A macromonomeric stabilizer, a preparation method thereof, a method for preparing a polymeric polyol using same, and the polymeric polyol prepared. Also disclosed are a soft polyurethane foam obtained by foaming a composition of the polymeric polyol prepared and a polyisocyanate, and a molded product comprising the soft polyurethane foam. The preparation method of the macromonomeric stabilizer comprises the following steps: reacting a polyol with a tricarboxylate not comprising a polymerizable ethylenically unsaturated double bond, or a derivative thereof, to form an adduct; and reacting the resulting adduct with an epoxide comprising a polymerizable ethylenically unsaturated double bond. The macromonomeric stabilizer of the present invention has a low viscosity, comprises a plurality of active sites, and can be directly used in subsequent reactions. The preparation method of the macromonomeric stabilizer can be carried out under normal pressure, without the need for end-blocking with ethylene oxide.

Macromonomeric stabilizer, preparation method thereof, and method for preparing polymeric polyol

Provided are a modified polyether polyol and the use thereof in polyurethane foam materials. The method for preparing a modified polyether polyol comprises the following steps: 1) reacting a compound A with a polyether polyol, wherein the compound A is an anhydride and/or dicarboxylic acid compound containing a polymerizable double bond, preferably selected from one or two of maleic anhydride and itaconic anhydride, preferably maleic anhydride; and 2) reacting the product obtained in step 1) with an epoxy compound containing a polymerizable double bond in the presence of a catalyst, in order to prepare the modified polyether polyol. The modified polyether polyol obtained by means of the preparation method has more active sites, uses the polymerizable double bond for blocking, is used as a dispersion stabilizer for the synthesis of copolymer polyols, and has the characteristics of a better dispersion stability, filterability and a low viscosity.

Modified polyether polyol and use thereof in polyurethane foam materials

A multi-wavefield seismic detection method and system based on construction noise of a shield machine. Multi-wavefield seismic information such as a body wave and a surface wave formed during propagation of a seismic wave generated by excitation in a stratum is obtained by using noise information caused by the construction of a shield machine as a seismic source, a stratum velocity model along a tunnel is constructed through joint inversion, and reflection wave information or the like is used for migration imaging, to eventually implement relatively accurate detection of a geological condition in front of a tunnel face of shield construction.

Multi-wavefield seismic detection method and system based on construction noise of shield machine

The present invention discloses a system and method for phased array sound wave advanced geological exploration for a shield tunneling machine. The system includes a phased array sound wave emitting and receiving apparatus, a probe automatic telescopic apparatus, an automatic protection and cleaning apparatus, and a signal processing and imaging system. Sonic probes are installed on a side wall of a main spoke, opposite to a rotation direction, of a cutterhead of the shield tunneling machine, on the basis of automatic detection of a telescopic state and a contact state, sonic array probes are enabled to make contact with a tunnel face by a hydraulic push rod, a focus sound wave is emitted by using a phased array emitting technology, and a reflected wave signal with front geological information reflected from the front of the tunnel face is received. A scanning direction of a sound wave beam is controlled and changed continuously through a host system, on the premise of obtaining a suspected abnormal body position, the suspected position is imaged in detail by using a focusing image till scanning of a whole two-dimensional section is completed, then the cutterhead is rotated to change an arrangement direction of an array to continue scanning of a next two-dimensional section, and finally three-dimensional geological exploration in front of the tunnel face is realized.

System and method for phased array sound wave advanced geological exploration for shield tunneling machine

A horizontal jet-mechanical combined rock breaking test device and method. The device includes a horizontal base. One end of the horizontal base is provided with a multi-mode cutter head. A jet-mechanical combined cutter is provided on the multi-mode cutter head. The other end of the horizontal base is provided with a surrounding rock stress simulation bin for loading a rock sample. The multi-mode cutter head is connected to a driving mechanism, and the multi-mode cutter head is configured to advance and rotate horizontally along the horizontal base under the action of the driving mechanism, so that the jet-mechanical combined cutter is capable of acting on the rock sample.

Horizontal jet-mechanical combined rock breaking test device and method

An automatic test system and method for mechanical parameters of surrounding rock applicable to a TBM. The system includes: an aggregate portion collecting a rock slag in a TBM tunneling process in real time; a gripping portion gripping any rock slag from obtained rock slags; a visual processing apparatus performing three-dimensional imaging for a rock slag under test in an infrared ranging manner; calculating positions of loading points for an abrasiveness test experiment, and determining, based on a spacing between loading points, whether rock slag under test meets a requirement; and determining actual positions of loading points if the rock slag under test meets the requirement, and determining a region, on a surface of rock slag, that meets a set condition as an action region for abrasiveness test experiment; and a rock abrasiveness test apparatus automatically performing an abrasiveness test for a rock slag under test that meets a requirement.

Automatic test system and method for mechanical parameters of surrounding rock applicable to TBM

Growing community of inventors

Jinan, China

Bin Liu