Millennium Pharmaceuticals Limited

Bin Li

Stephen J Blakemore

Peter G Smith

George J Mulligan

William L Trepicchio

Matthew C Schu

Hyunjin Shin

Disclosed herein are markers associated with sensitivity to treatment with therapeutic agents. Methods to identify markers for predicting outcome to treatment with a therapeutic agent are disclosed as well as methods to predict outcome of treatment using markers. Compositions and methods are provided to predict response to NAE inhibition or EGFR inhibition treatment.

Biomarkers and methods to predict response to inhibitors and uses thereof

Disclosed herein are markers whose mutational status is associated with sensitivity to treatment with NAE inhibitors. Mutational status is determined by measurement of characteristics of markers associated with the marker genes. Compositions and methods are provided to assess markers of marker genes to predict response to NAE inhibition treatment.

Biomarkers of response to NAE inhibitors

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Belmont, MA, United States of America

Bin Li