Welichem Biotech Inc.

Weihe Pharma{grave Over (c)}euticals Co. Ltd.

Celestial Pharmaceuticals (shenzhen) Ltd.

Yunnan Weihe Pharmaceuticals Co. Ltd.

Bin Li

Genhui Chen

Jianxiong Li

John M Webster

Kaiji Hu

Yingping Guo

The present invention provides novel dithiolopyrrolone compounds and their salts, which are useful as treatments for cancer and other proliferative diseases. The present invention also provides therapeutic compositions comprising particularly useful types of dithiolopyrrolones, the salts thereof, and methods of using the compounds within such types, particularly in treating proliferative diseases such as cancer.

Dithiolopyrrolones with therapeutic activity

The present invention provides dithiolopyrrolone compounds of the general formula I, and their salts, wherein A is sulfur or carbon, and R, R, and Rare selected from groups defined herein, and wherein when A is sulfur, then B is oxygen, and n=1 or 2, and when A is carbon, then B is oxygen or sulfur, and n=1. The compounds are useful for the prevention and treatment of microbial infections such as HIV infection, and for the treatment of blood disorders, such as neutropenia. In particular, the compounds are useful for the manufacture of medicaments for increasing white blood cells. 

Dithiolopyrrolones compounds and their therapeutic applications

The invention is drawn to novel macrolide compounds of formula I having antibiotic and antineoplastic activities, useful as medicaments and/or agrochemicals for microorganism infections, in particularly for infectious diseases involving drug-resistant, and for treatment of human and animal cancers. 

Macrolide compounds with antibiotic and antineoplastic properties

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Burnaby, Canada

Bin Li