Ohio State Innovation Foundation

Bin Li

Yizhou Dong

The present disclosure generally relates to genome editing systems and methods and compounds and compositions for use in Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) genome editing systems. Disclosed herein are modified nucleic acids that modulate the activity of genome editing.

Modified nucleic acids, hybrid guide RNAS, and uses thereof

The present disclosure generally relates to systems, methods and compositions for use in Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cpf1 genome editing systems.

Engineered guide RNA and uses thereof

The present disclosure generally relates to systems, methods and compositions for use in Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cpf1 genome editing systems. Disclosed herein are modified Cpf1 mRNAs, modified guide RNAs, and combinations thereof, that confer increased levels of genome editing.

Modified Cpf1 MRNA, modified guide RNA, and uses thereof

Modified nucleic acids, hybrid guide RNAs, and uses thereof

The present invention relates to compounds, compositions, lipid-like nanoparticles, and methods for delivery of therapeutic, diagnostic, or prophylactic agents (for example, a polynucleotide).

Growing community of inventors

Columbus, OH, United States of America

Bin Li