University of Akron

University of Pittsburgh

Bin Cao

Gang Cheng

Qiong Tang

Xinyan Cui

A method of forming a compound having the formula (I'): (I&#x2032;) includes the reaction: (II&#x2032;) in the presence of a base, wherein X is a halo atom selected from the group consisting of Cl, Br and I. 

Synthesis of functionalizable or functionalized poly(3,4-ethylenedioxythiphene)-based polymers and monomers therefor

Various embodiments of the present invention are directed to switchable carboxybetaine-based polymers, hydrogels, and/or elastomers, along with novel related monomers, crosslinkers, and methods. Under acidic conditions, the materials undergo self-cyclization and can catch and kill bacteria. Under neutral/basic conditions, these materials undergo ring-opening and can release killed bacterial cells and resist protein adsorption and bacterial attachment. These smart polymers, hydrogels and elastomers also show excellent mechanical properties making them highly desirable for many biomedical applications.

Switchable antimicrobial and antifouling carboxybetaine-based hydrogels and elastomers with enhanced mechanical properties

One or more embodiments of the present invention provide a novel composition for gene delivery are directed to a group of polysaccharide polymers, having one or more nucleic acid delivery side chains comprising cationic peptides. In some embodiments, these cationic peptides condense and physically bond to one or more nucleic acids to form a polysaccharide-nucleic acid complex that permits delivery to and transfection of the nucleic acid(s) into cells. In some embodiments, the polysaccharide polymers of the present invention may also have one or more zwitterionic side chains and/or reactive side chains.

Dextran-peptide hybrid for efficient gene delivery

A high drug loading system is described comprising of at least one anticancer drug; at least one peptide; and at least one nucleic acid.

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Allison Park, PA, United States of America

Bin Cao