Schering Corporation

Bimalendu Dasmahapatra

Bernard R Neustadt

Alan K Mallams

Jonathan A Pachter

Henry A Vaccaro

Mark Demma

Nancy J Butkiewicz

The present invention provides compositions as well as methods for identifying compositions useful for treating or preventing cancer.

p53 modulators

Hybrid regulatory proteins are provided which contain amino acid sequences that are susceptible to cleavage by specific proteolytic enzymes. When acted upon by such enzymes, the hybrid regulatory proteins are rendered substantially less active, thereby altering the rate of production of products of indicator genes that are controlled by the regulatory proteins. Also provided are DNAs encoding such regulatory proteins, recombinant vectors and transformed eukaryotic cells containing such DNAs, and methods for identifying inhibitors of the specific proteolytic enzymes.

Protease assays

Soluble covalent HCV NS3-NS4A complexes comprising the catalytic domain of native HICV NS3 protease fused to an HCV NS4A cofactor, wherein the cofactor has been modified to prevent cleavage by the HCV NS3 protease.

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Nutley, NJ, United States of America

Bimalendu Dasmahapatra