The University of Texas System

Bimal K Banik

Frederick F Becker

Provided herein are polycyclic &#x3b2;-lactam compounds, compositions thereof and methods for the treatment and prevention of diseases such as cancer, including pancreatic cancer and pancreatic cancers resistant to mainline chemotherapeutic agents.

Polycyclic &#x3b2; lactam derivatives for the treatment of cancer

Antitumor dibenzofluorene derivatives

Dibenzofluorene derivatives having a formula selected from the group consisting of

Chrysene derivatives having the formula ##STR1## have been found to have antitumor activity. In the above formula, at least one of R.sub.1 -R.sub.12 is --R.sub.13 Z, where R.sub.13 is a substituted or unsubstituted amino or amido group having from 1-12 carbon atoms, and Z is a substituted or unsubstituted heterocyclic group having from 1-12 carbon atoms; and the remainder of R.sub.1 -R.sub.12 are independently selected from the group consisting of hydrogen, substituted or unsubstituted amino or amido groups having 1-12 carbon atoms, nitro, and substituted or unsubstituted hydrocarbyl groups having from 1-12 carbon atoms.

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Missouri City, TX, United States of America

Bimal K Banik