E.i. Dupont De Nemours and Company

Pioneer Hi-bred International, Inc.

Verdia Inc.

E. I. Du Pont De Nemours

University of California

Pioneer Hi-bred Int'l Inc.

The Texas A&m University System

Other

University System of Maryland

Billy Fred McCutchen

Albert Laurence Lu

Rafael Herrmann

James Kevin Presnail

James F H Wong

Andre R Abad

Janet Ann Rice

Carl R Simmons

Ronald D Flannagan

James F Wong

Jeremy S Minshull

Rebecca E Cahoon

Phillip A Patten

Nicholas B Duck

Lorraine Joan Giver

Linda A Castle

Yong Hong Chen

Daniel J Altier

Rebecca Lynne Gorton

Dan Siehl

Cao Guo Yu

Roger Kemble

Leslie T Harvell

Pedro A Navarro Acevedo

Cristina Ivy

Eric J Schepers

Christine B Hazel

Donglong Liu

Cao-Guo Yu

Janine L Weaver

Clement W K Waine

Timothy K Chicoine

Kenneth A Peeples

David W Saunders

Scott H Diehn

Nasser Yalpani

Lynne Eileen Sims

Tamas Torok

Kim R Ward

Jennie Hunter-Cevera

Natalia Ellanskaya, Legal Representative

Glen Dahlbacka

Bruce D Hammock

Hua Dong

Guo-Hua Miao

James C Sacchettini

Nian E Zhou

André Abad

Christina Ivy

Manchi C M Reddy

Jerry M Green

Wayne J Mehre

Omolayo O Famodu

Zude Weng

Jeffrey M Hegstad

Mark D Vogt

James M Hutchison

Jeffery W Derry

Irina Elleskaya

J Antoni Rafalski

Xiaomei Shi

Gan-Yuan Zhong

Paul D Olson

Theodore W Kahn

Rama M Belagaje

Irina Ellanskaya

Susumu Maeda

Susan B Lo

Elizabeth Fowler

Eliahu Zlotkin

Bin Hu

Xiaofeng Sean Yang

James Fh Wong

Jeremy Minshull

I A Elleskaya

Compositions and methods for inhibiting and/or sensitizing or re-sensitizing a parasite to an antiparasitic drug are provided. The compositions can comprise a an arylphenoxypropionate derivative, an aryloxyphenoxyacetate derivative, an aryloxyphenylacetate derivative, one or more substituted quinols, or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, or a combination thereof in an amount and formulation sufficient to sensitize the parasite to the drug, treating infection of a patient by a parasite with a drug, or to prevent symptomatic infection of a patient by a parasite with a drug.

Compositions and methods for drug sensitization of parasites

A composition comprising a drug selected from the group consisting of an arylphenoxypropionate derivative, an aryloxyphenoxyacetate derivative, an aryloxyphenylacetate derivative, a substituted quinol, or a salt, hydrate, or prodrugs thereof, or a combination thereof, in an amount and formulation sufficient to inhibit ais disclosed.

Compositions and methods for inhibition of mycobacteria

Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.

Defensin polynucleotides and methods of use

Methods and compositions are provided related to improved plants that are tolerant to more than one herbicide. Particularly, the invention provides plants that are tolerant of glyphosate and are tolerant to at least one ALS inhibitor, and methods of use thereof. The glyphosate/ALS inhibitor-tolerant plants comprise a polynucleotide that encodes a polypeptide that confers tolerance to glyphosate and a polynucleotide that encodes an ALS inhibitor-tolerant polypeptide. In specific embodiments, a plant of the invention expresses a GAT polypeptide and an HRA polypeptide. Methods to control weeds, improve plant yield, and increase transformation efficiencies are provided.

Methods and compositions for providing tolerance to multiple herbicides

Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention, or variant or fragment thereof, are also disclosed.

Antifungal polypeptides

Methods and compositions for identifying novel genes that share regions of homology with known genes from target groups of genes of interest are provided. The methods comprise systematically designing oligonucleotide primers that are specific for regions of homology within the nucleotide sequences of a target group of known genes and performing successive rounds of PCR amplification of nucleic acid material from an organism of interest. The PCR steps are intended to identify and amplify nucleic acids comprising both known and novel genes. Nucleic acid molecules comprising known genes are detected and eliminated from further consideration by dot blot analysis using oligonucleotide probes specific for the known genes in the target group. Potentially novel genes are subjected to further sequence analysis to confirm novelty and assayed for biological activity. Compositions of the present invention include novel polynucleotides, and variants and fragments thereof, that comprise novel genes and the polypeptides encoded thereby.

Method for identifying novel genes

Proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are polynucleotides capable of encoding these proteins, compositions that include one or more of these proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these compounds, diversification methods involving the compounds, and methods of using the compounds. Some of the methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.

Glyphosate-N-acetyltransferase (GAT) genes

Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.

Nucleic acid molecules encodng a cathepsin L-like cysteine protease

Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.

Growing community of inventors

Clive, IA, United States of America

Billy Fred McCutchen