Immunovaccine Technologies Inc.

Dalhousie University

Horizon Technology Finance Corporation

Bill Pohajdak

Wijbe M. Kast

Marc Mansour

Pirouz M. Daftarian

Robert G. Brown

Robert George Brown

Warwick Charles Kimmins

Michael Mezei

Pirouz M Daftarian

Wijbe M Kast

James R Wright, Jr

Leslie McLaren

Janet Horrocks

Robert G Brown

The invention compositions comprising a continuous hydrophobic phase and liposomes as a vehicle for delivery of an antigen capable of inducing a cytotoxic T lymphocyte (CTL) response and methods for their use in the treatment of cancer.

Use of liposomes in a carrier comprising a continuous hydrophobic phase as a vehicle for cancer treatment

The present invention is concerned with vaccines and their preparation. An effective long-term immune response, especially in mammals, can be produced using a vaccine comprising an antigen encapsulated in liposomes, a suitable adjuvant and a carrier comprising a continuous phase of a hydrophobic substance. The vaccine is particularly effective in eliciting the production of antibodies that recognize epitopes of native proteins.

Vaccines with enhanced immune response and methods for their preparation

The present invention provides immunocontraceptive vaccines comprising a zona pellucida (ZP) polypeptide, and/or a variant thereof, from a carnivorous mammal such as cat, dog, ferret or mink. Such vaccines are useful in reducing fertility of cats and/or dogs.

Antigens for immunocontraception

Disclosed is an immunocontraceptive vaccine composition comprising a teleost homolog of zona pellucida (TH-ZP), together with a pharmaceutically acceptable diluent or carrier, for reducing or preventing fertilization in a fish, and a method for its use. Also disclosed is immunocontraceptive vaccine composition comprising an antigen from an inner perivitelline layer (IPVL), together with a pharmaceutically acceptable diluent or carrier, for reducing or preventing fertilization in a bird, and a method for its use.

Compositions and methods for reducing or preventing fertilization in fish and birds

In accordance with the present invention, there are provided humanized fish insulin genes. Humanized insulin the present invention encode human insulin alpha and/or beta chains while using fish-preferred codons and regulatory sequences. These humanized genes are thus expressible in fish islet cells. Also provided are transgenic fish having islet cells containing and capable of expressing humanized insulin genes. These islet cells (Brockmann Bodies) can be xenotransplanted into subjects having diabetes. In this manner normoglycemia can be achieved in the recipient of the islets.

Transgenic tilapia comprising a humanized insulin gene

A vaccine for the immunocontraception of mammals is described. The vaccine consists of zona pellucida antigens and an adjuvant encapsulated in a liposome delivery system. The liposome delivery system allows for the slow release of antigen resulting in a prolonged immune response. In particular, after a single injection of the vaccine, levels of anti-zona pellucida antibodies were detected for up to 22 months in seals. Thus, the vaccine according to the present invention is effective after a single dose and is therefore very useful in immunocontraceptive protocols.

Method to prevent fertilization in mammals by administering a single dose of zona pellucida derived antigens, liposome and adjuvant

Transgenic fish and a method of harvesting islet cells therefrom

Method to prevent fertilization in mammals by administering a single

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Dartmouth, Canada

Bill Pohajdak