University of South Florida

The UAB Research Foundation (The University of Alabama at Birmingham)

The United States Government As Represented by the Department of Veterans Affairs

King Abdulaziz University

University of Central Florida Research Foundation Inc

Instituto Politecnico Nacional

Spraingo, LLC

Norwegian University of Life Sciences (nmbu)

Bill J Baker

Charles Dunkle Amsler, Jr

James Bruce McClintock

Dennis Edward Kyle

Chad Dickey

Lindsey Neil Shaw

Laurent Calcul

Matthew Lebar

Umesh Kumar Jinwal

Renee Marie Fleeman

Ala Azhari

Thushara Diyabalanage

Danielle H Demers

Anne-Claire D Limon

Jeffrey Jones

Andrew Jason Shilling

Alexandre Jean Bory

Jessie Allen (Adams)

Nerida G Wilson

Sofia Kokkaliari

John H Adams

James William Leahy

Kyle Rohde

Alison Elizabeth Roth

John Alan Maschek

Brian Vesely

Marisa Fuse

Bingjie Yang

Mario Alberto Rodriguez-Pérez

Kim Pham

Jacqueline Lee Fries

Christopher G Witowski

Alexander Dettmar Crawford

Nargess Shahbazi

Witowski G Christopher

Lindsey N Shaw

Thusahara Diyabalanage

Matthew A Knestrick

Wayne Caleb Williams

Described herein arecompounds and derivatives thereof. Also described herein are formulations that can contain an amount of one or morecompounds or derivatives thereof and a carrier. Also described herein are methods of administering one or morecompound and/or derivative thereof or a formulation thereof to a subject in need thereof.

compounds, derivatives thereof, and uses thereof

Pharmaceutical compositions containing one of five novel alkaloids isolated from a deep water Antarctic tunicate and methods of uses thereof are presented. The alkaloids belong to a family of compounds with known central nervous system (CNS) activity. The compounds display more oxidation than other members of the family, which may bestow additional bioactivity.

Antarctic tunicatespecies-derived alkaloids and methods of treatment

Described herein are methods of epigenetic modification of fungi and uses thereof. Also described herein are compounds that can have antileishmanial activity and formulations thereof. Also described herein are methods of treating leishmanial infection in a subject that include the step of administering a compound or formulation thereof described herein to the subject.

Epigenetic modification of fungi and uses thereof

The present disclosure provides methods for the treatment of infections withsuch asor leprosy.

Methods for the treatment ofinfections

The present disclosure is directed to methods for the treatment of inflammation or pain, particularly methods using compositions containing a compound of formula (I).

Methods for the treatment of inflammation

The present disclosure relates to methods of modifying complex extracts such that components or mixtures of components are selectively removed or added, thus providing a complex mixture that does not naturally occur with a refined or a tuned therapeutic or nutraceutical effect. In various aspects, the complex extract can be an extract obtained from one or more plants, e.g., an extract obtained from green tea leaves. The present disclosure pertains to compositions obtained by the disclosed methods, nutraceutical compositions comprising same, pharmaceutical compositions comprising same, and methods of treating various conditions, including physiological dysfunctions associated with elevated reactive oxygen species and/or inflammatory molecule, e.g., TNF&#x3b1;, expression using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Methods and compositions for modulating complex mixtures by selective deletion chromatography

Described herein are compounds, formulations, and methods for blocking sporozoite invasion and subsequent liver-stage parasite development of a protozoan parasite, such as

Compounds and methods for inhibiting protozoan parasites

Provided is a darwinolide compound having a previously undescribed carbon skeleton and the crystalline form thereof. Also provided are processes of isolating darwinolide, compositions comprising darwinolide, and methods of treating infection, such as a methicillin-resistantbiofilm infection.

MRSA biofilm inhibition

In one aspect, methods and compositions for treating parasitic diseases, for example, leishmaniasis.

Leishmania inhibitors

The present invention concerns groups of compounds derived from tunicates of thespecies, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.

Cytotoxin compounds and methods of isolation

Novel antimicrobial compounds against drug targets such as Eskape pathogens,, and cancer are presented herein.

Antimicrobials from an epigenetics based fungal metabolite screening program

The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.

Myricanol derivatives and uses thereof for treatment of neurodegenerative diseases

Growing community of inventors

Tampa, FL, United States of America

Bill J Baker