Yeda Research and Develpment & Co. Ltd

Yeda Research and Development Ltd.

Bilha Schechter

Michael Sela

Yosef Yarden

Ruth Maron

Tsipi Ben-Kasus

Ruth Arnon

Meir Wilchek

Abraham Shanzer

Abraham Warshawsky

Michal Neeman

Amos Breskin

Rachel Chechik

Georg Mahlknecht

Zvi Paltiel

Monomeric and multimeric aptamers are provided. Also provided are pharmaceutical compositions which comprise same and methods of using same.

Aptamers, multimeric aptamers and uses thereof

A method of identifying a combination of antibodies with a combined improved anti-tumor activity is provided. The method comprising: (a) identifying binding epitopes of anti ErbB-2 antibodies; and (b) selecting a combination of at least two antibodies of the anti ErbB-2 antibodies exhibiting binding to different epitopes on the ErbB-2, at least one of the different epitopes being localized to a dimerization site of the ErbB-2, the combination of antibodies being with the combined improved anti-tumor activity. Also provided are novel antibody combinations uncovered according to the present teachings.

Antibody combinations and use of same for treating cancer

An article-of-manufacture is provided. The article-of-manufacture comprises a packaging material identified for treating cancer, packaging: Also provided are pharmaceutical compositions and methods of using the above antibodies as well as other antibody combinations for the treatment of cancer.

Combinations of anti ErbB antibodies for the treatment of cancer

A delivery system and method for targeting a contrast agent to tissues and organs for improved diagnosis of tumors and for prognosis and follow-up of cancer therapy by X-ray imaging. The delivery system includes a conjugate or complex of a macromolecular carrier and a contrast agent selected from the group consisting of: (a) a compound having a heavy element with an atomic number in the range of 75 to 92, and (b) a compound having an element with a property of an abrupt change in its X-ray attenuation coefficient within the energy range used for radiography, said macromolecular carrier of said conjugate or complex being optionally linked to a specific tissue marker molecule.

X-ray imaging of tumors with dextran carrier of platinum compounds

The present invention relates to avidin-type molecules having 2,4,6-trinitrophenyl or lactosyl groups or being complexed with an antibody specific to the avidin-type molecule, which shifts the biodistribution pattern in tissues and organs to the liver, where these molecules accumulate at high levels over several days. These modified avidin-type molecules provide a means for delivery of diagnostic and therapeutic agents, including radionuclides to the liver and cells of the reticuloendothelial system (RES) for diagnosing and treating hepatic disorders and disorders of the RES.

Modified avidin-type molecules as targeting agents for the liver and cells of the reticuloendothelial system

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Rehovot, Israel

Bilha Schechter