Bar-Ilan University

Other

Universidad Complutense De Madrid

Bar-Llan University

University of Montpellier

Bilha Fischer

Victoria Nahum

Adrien R Beaudoin

Jesus Jeronimo Pintor

Shay Elyahu

Tamar Ginsburg-Shmuel

Einat Sharon

Victoria Kleiman-Nahum

Pierre Petit

Efrat Halbfinger

Fernand-Pierre Gendron

Yaron Shav-tal

Abed Elhady Saady

Eli Varon

The present invention is directed to styryl quinolinium compounds, a process for their synthesis and their use for selective nucleoli staining in cells, preferably in living cells and for imaging rRNA.

Styryl quinolinium, process for their preparation and use thereof as fluorescent probes for imaging

The disclosure provides particular uridine di- and tri-phosphate compounds of Formula I, and pharmaceutical compositions thereof. The definitions of variables such as R, Y, B, m, Z, Z, and Zare as provided in the disclosure. These compounds are useful for treatment of diseases, disorders and conditions modulated by P2Yreceptors, and particularly for lowering intraocular pressure and thereby treating ocular hypertension and/or glaucoma. 

Uridine di- or tri-phosphate derivatives and uses thereof

The invention relates to fluorescent N,N3-etheno-purine (2'-deoxy) riboside derivatives and fluorescent oligonucleotide probes comprising one or more moieties thereof, their preparation and uses thereof for staining DNA/RNA and for detection and quantitation of genetic material.

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The present invention provides dinucleoside boranophosphate derivatives of the general formula I:  wherein X and X' each independently is an unsubstituted or substituted purine or pyrimidine residue; Y and Y&#x2032; each independently is H or OH; Zto Zeach independently is Oor BH, but excluding the compounds wherein Zto Zare each O; Wto Weach independently is O, CH, NH or C(Halogen); n and n&#x2032; each independently is 0 or 1; m is 3, 4 or 5; and Mrepresents a pharmaceutically acceptable cation, and to pharmaceutical compositions thereof. These dinucleoside boranophosphates are useful for prevention or treatment of diseases or disorders modulated by P2Y receptors such as type 2 diabetes, cystic fibrosis and cancer.

Dinucleoside poly(borano)phosphate derivatives and uses thereof

The invention provides novel inorganic boranophosphate salts that can be used as fertilizers, in detergent formulations, as additive in melts for the glass industry, in boron neutron-capture therapy of cancer, and as synthetic building blocks in the synthesis of boranonucleotides of various lengths.

Inorganic boranophosphate salts

2-Substituted-5'-O-(1-boranotriphosphate)adenosine derivatives having at position 2 a radical R1 selected from the group consisting of H; halogen; O-hydrocarbyl; S-hydrocarbyl; NR3R4; and hydrocarbyl optionally substituted by halogen, CN, SCN, NO2, OR3, SR3 or NR3R4; wherein R3 and R4 are each independently H or hydrocarbyl or R3 and R4 together with the nitrogen atom to which they are attached form a saturated or unsaturated heterocyclic ring optionally containing 1-2 further heteroatoms selected from oxygen, nitrogen and sulfur, and pharmaceutically acceptable salts or diastereoisomers thereof or a mixture of diastereoisomers, are useful for treatment of type 2 diabetes.

Antidiabetic 2-substituted-5'-O-(1-Boranotriphosphate) adenosine derivatives

C8-substituted purine nucleotide analogs, such as ATP analogs, and their use is described, including their use as inhibitors of NTPDases and thereby as tools to modulate the conversion of nucleotides into nucleoside derivatives, and thus modulate the levels of these compounds. Such modulation further provides for the modulation of the activity and function of many processes which are affected by these compounds.

Growing community of inventors

Shoham, Israel

Bilha Fischer