Medarex Inc.

Bristol-myers Squibb Compnay

E. R. Squibb Sons, Inc.

Bilal Sufi

Haichun Huang

Sanjeev Gangwar

Josephine M Cardarelli

Vincent Guerlavais

Liang Chen

Zhi-Hong Li

Naidu S Chowdari

Sharon Elaine Boyd

David B Passmore

Chin Pan

Kilian Horgan

Killian Horgan

Sharon Boyd

Sanjeev Ganwar

David John King

Enediyne compounds having a structure according to formula (I), where R, R, R, R, R, R, and Rare defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer. 

Enediyne compounds, conjugates thereof, and uses and methods therefor

The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Chemical linkers and cleavable substrates and conjugates thereof

The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Chemical linkers and conjugates thereof

The present disclosure provides cytoxic compounds useful as drugs or prodrugs and to drug-cleavable substrate conjugates where the drug and cleavable substrate are optionally linked through a self-immolative linker.

Cytotoxic compounds and conjugates

The present disclosure provides drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-cleavable substrate conjugates, and to methods of treatment using them.

Cytotoxic compounds and conjugates with cleavable substrates

Growing community of inventors

Santa Clara, CA, United States of America

Bilal Sufi