Abbott Laboratories Corporation

Bikshandar A Narayanan

Steven J Wittenberger

Yun He

Anthony Ralph Haight

Nan-Horng Lin

William H Bunnelle

David Scarpetti

Richard L Elliott

Pulla Reddy Singam

Mukund S Chorghade

Dieter O Beer

Christian C Witzig

Thomas C Herzig

Thomas K Esch

Alla V Rama Rao

A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C.sub.1 -C.sub.3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

Method of preparing enantiomerically-pure

The present invention relates to a process for the preparation of 5-aryl tetrazoles of the formula: ##STR1## or a salt thereof comprising reacting an aryl nitrile with a trisubstituted silyl azide and a disubstituted tin oxide.

Process for the preparation of tetrazoles

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Mundelein, IL, United States of America

Bikshandar A Narayanan