University of Michigan

Nara Institute of Science and Technology

Bikash Sahoo

Jun-ichi Kikuchi

Thirupathi Ravula

Ayyalusamy Ramamoorthy

Kazuma Yasuhara

Jin Arakida

The disclosure generally relates generally to lipid nanodiscs, in particular to lipid nanodiscs formed from acryloyl-based copolymers. A lipid nanodisc according to the disclosure includes a lipid bilayer having a first hydrophilic face and a second hydrophilic face opposing the first hydrophilic face, and a hydrophobic edge between the opposing hydrophilic faces, and an acryloyl-based copolymer encircling the hydrophobic edge of the lipid bilayer. The acryloyl-based copolymer includes a first monomer unit having a pendant hydrophobic group and a second monomer unit having a pendant hydrophilic group. Methods of making and characterizing the lipid nanodiscs are also disclosed.

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Ann Arbor, MI, United States of America

Bikash Sahoo