University of Florida Research Foundation Inc

Rise Therapeutics, LLC

Bikash Sahay

Mansour Mohamadzadeh

Yaima L Lightfoot

Christian Furlan Freguia

Jyoti Jha

Gary Fanger

The current invention provides a recombinant bacterium, the recombinant bacterium being genetically modified to synthesize surface layer protein A (SlpA). Efficacious therapies for a subject suffering from an inflammation mediated disease are also provided. The methods of the current invention comprise administering to a subject in need thereof a therapeutically effective amount of the recombinant bacterium, for examplecells, or a therapeutically effective amount of the isolated SlpA. The recombinant bacteria cells or SlpA isolated from the recombinant bacteria can be in a pharmaceutical composition comprising a pharmaceutically acceptable carrier and/or excipient.

Surface layer protein a (SlpA) as a therapeutic agent for the treatment of inflammatory diseases

The current invention provides a recombinant bacterium, the recombinant bacterium being genetically modified to decrease or eliminate the display of lipoteichoic acid (LTA), surface layer protein B (SlpB) and surface layer protein X (SlpX) on the surface of said bacterium. Efficacious therapies for a subject suffering from an inflammation mediated disease are also provided. The methods of the current invention comprise administering to a subject in need thereof a therapeutically effective amount of the recombinantcells or a therapeutically effective amount of the isolated surface layer protein A (SlpA) or a non-naturally occurring derivative thereof. The recombinantcells or SlpA isolated fromcan be in a pharmaceutical composition comprising a pharmaceutically acceptable carrier and/or excipient. In an embodiment of the invention, the pharmaceutical composition is administered orally.

surface layer protein A (SLPA) as a therapeutic agent for the treatment of inflammatory diseases

surface layer protein a (SlpA) as a therapeutic agent for the treatment of inflammatory diseases

surface layer protein A (SlpA) as a therapeutic agent for the treatment of inflammatory diseases

Growing community of inventors

Gainesville, FL, United States of America

Bikash Sahay