Tsinghua University

Dcb-usa LLC

National Taiwan University

National Health Research Institutes

Taipei Medical University

Biing-Jiun Uang

Ping-Yu Wu

Wei-Ming Huang

Hsyueh-Liang Wu

Hsing-Pang Hsieh

Jang-Yang Chang

Feng-Lin Hsu

Chun-Cheng Lin

Shing-Hwa Liu

Chih-Hao Tseng

Yu-Han Tsao

Wun-Shaing Wayne Chang

Bo-Yao Yang

Jo-Chun Chen

Chi-Rui Wu

The present invention relates to a method of enantioselective addition to imines, including: reacting RCH&#x2550;NY with RZnRin the presence of a compound represented by the following formula (I), 

Method of enantioselective addition to imines

Cathepsin S inhibitors having formula (I), (II), (III) or (IV) as shown in the specification. These inhibitors can be used to treat cancer and autoimmune/inflammatory diseases.

Cathepsin S inhibitors

A method for preparing 2-morpholinoisobornane-10-thiol is disclosed, which has simplified steps and avoids the use of Na metal. Accordingly, it is advantageous to apply the method in a mass production.

Method for preparing 2-morpholinoisobornane-10-thiol and intermediates formed therein

This invention relates to the use of pterosin compounds of formula I for treating diabetes including type I and type II. Also disclosed is the use of the pterosin compounds for treating obesity.

Use of pterosin compounds for treating diabetes and obesity

Camphor-derived compounds are disclosed, which are represented as the following formula (I): 

Camphor-derived compounds, method for manufacturing the same, and application thereof

A novel camphor-derived &#x3b2;-amino alcohol compound is disclosed. The novel camphor-derived &#x3b2;-amino alcohol compound can be used in asymmetric addition of organozinc to aromatic and aliphatic aldehydes, including linear aliphatic ones, thus generating corresponding secondary alcohols in high yields and enantiomeric excess.

Camphor-derived &#x3b2;-amino alcohol compounds, method for manufacturing the same and asymmetric addition of organozinc to aldehydes using the same

The present invention relates to a method of enantioselective addition to enones, including: reacting R(CH)CH&#x2550;CRC(&#x2550;O)Y(CH)Rwith RZnRin the presence of a compound represented by the following formula (I) and a transition metal catalyst, 

Method of enantioselective addition to enones

A method for preparing a propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol (MITH) is disclosed, which includes reacting RCHO with RCCH in the presence of RZnRand MITH, wherein each of R, R, R, and R, independently, is optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkylsilyl, heterocycloalkyl, heterocycloalkenyl, aryl, aryloxy, or heteroaryl. The method can give enantioenriched propargylic alcohols with good enantioselective at low loading of MITH.

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Hsinchu, Taiwan

Biing-Jiun Uang