Nhwa Pharma. Corporation

Huazhong University of Science and Technology

Wuhan Jiayu Technology Co., Ltd.

Bifeng Liu

Guisen Zhang

Xiangqing Xu

Yin Chen

Minquan Yu

Xin Liu

Song Zhao

Yinli Qiu

Shicheng Liu

Heng Zhang

Tan Zhang

Yifang Zhang

Xinghua Liu

Xudong Cao

Xiaojun Feng

Yu Lan

The present invention relates to the field of pharmaceutical chemistry, and specifically relates to a fused heterocyclic compound derivative and an application thereof. The fused heterocyclic compound derivative has the structure of general formula (I), and can be used to treat neuropsychiatric diseases. 

Fused heterocyclic compound derivative and application thereof

The present invention relates to the field of pharmaceutical chemistry, and in particular, to a benzopyrone derivative and a use thereof. The benzopyrone derivative is compound having a structure of formula (I) or a pharmaceutically acceptable salt thereof. It has been found by experiments that, this type of compounds is useful in prevention or treatment of neuropsychical diseases. 

Benzopyrone derivative and use thereof

Disclosed are alicyclic[c]benzopyrone derivatives and use thereof. The alicyclic[c]benzopyrone derivatives are compounds represented by formula I or their salts. The present compounds not only significantly improve high activity induced by MK-801, but also effectively improve clambering symptom induced by Apomorphine and do not cause EPS within effective dose. These in vitro targets and in vivo pharmacological models are closely related to diseases of the nervous system caused by dopamine dysfunction, especially schizophrenia. Therefore the present compounds can be used for the treatment of central nervous system diseases, especially schizophrenia. EDis lower and effect is stronger in two animal models i.e. high activity induced by MK-801 and clambering symptom induced by Apomorphine, while EDis higher and therapeutic index is greater in animal models of catalepsy. 

Alicyclic[c] benzopyrone derivatives and uses thereof

The present invention belongs to the medicinal chemistry field, and specifically discloses a [1,3,4]oxadiazole derivative with the structure of general formula (I) and pharmaceutically acceptable salt thereof. The compound can be used to prepare a medicine for preventing or treating a disease of the central nervous system. 

[1,3,4] oxadiazole derivative and application thereof

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Hubei, China

Bifeng Liu