International Business Machines Corporation

Bhuvan Sharma

Kirk Alan Beaty

Vanessa V Michelini

Fang Wang

Cheryl L Eifert

Claudia S Huettner

Mengdi Zhu

Jia Xu

Marta Sanchez-Martin

Pengwei Yang

Elinor Dehan

Jose I Ramirez

Shang Xue

Himanshu Sharma

A mechanism is provided for processing electronic files to identify genetic variants of a gene. Evidence of one or more genetic variants of the gene and corresponding information is extracted from a corpus of information. Each genetic variant of the one or more genetic variants is classified based on whether the genetic variant is identified as being pathogenic. Genetic variant annotation is then performed to generate a summary.

Automatic processing of electronic files to identify genetic variants

A computer system updates a knowledge graph. A model corresponding to a set of documents is received, wherein the model comprises a plurality of entities, a plurality of entity associations, and a plurality of confidence scores corresponding to the plurality of entity associations. A relevance value is calculated for each entity of the plurality of entities that are present in the set of documents and for each entity of the plurality of entities that are present in a new document. One or more entity associations that are supported by specific portions of the new document are identified. The confidence scores for each of the identified one or more entity associations are updated based on a level of support in the new document. Embodiments of the present invention further include a method and program product for updating a knowledge graph in substantially the same manner described above.

Self-evolving knowledge graph

A method, a system, and a computer program product are provided. A first computing device determines that data to be processed for a request is confined to a geographic region in which the data is stored and identifies a second computing device within the geographic region in which the data is stored, wherein the identified second computing device and the computing device are connected to a network. The computing device directs the identified second computing to process the data within the geographic region to which the data is confined, according to the request, by one or more processing nodes executing on the identified second computing device.

Region based processing and storage of data

Computer-based methods, systems, and computer readable media for managing documents within a content repository or documents within the document subsets are provided. Documents may be pre-processed to be machine readable and classified within the content repository into one or more categories, based upon a number of times classification terms appear in a specific section of the document or based on an article type tag. Document subsets may be generated based on user-defined terms. Documents may be associated with specific cancer-types, genes, gene variants and drugs by comparing relevant search terms to specific sections of the documents. A request for processing the documents may include one or more of the search terms, pertaining to one or more from a group of gene, gene variant, drug, and cancer terms. A priority score may be determined for documents based on a frequency of one or more of the search terms in each of the specific sections, and the documents may be ranked from highest total priority score to lowest total priority score.

Automated document filtration and priority scoring for document searching and access

A computer system processes documents in a content repository. Each document of a plurality of documents is classified into one of a functional category and a clinical category. Each document is annotated using one or more corpora to generate document annotations. Documents satisfying one or more query terms are identified by comparing each query term to the document annotations. The identified documents are ranked based on a determined relevance. Guidelines are produced based on the ranking of the identified documents. Embodiments of the present invention further include a method and program product for processing documents in a content repository in substantially the same manner described above.

Processing documents in content repositories to generate personalized treatment guidelines

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Belmont, MA, United States of America

Bhuvan Sharma