Synphar Laboratories, Inc.

Taiho Pharmaceutical Company Limited

Bhupinder Palak

Inder Pal Singh

Ronald G Micetich

Ronald J Micetich

Paul Spevak

Inderjit Sidhu

Samuel Amedjo

The asymmetric production of pure diastereomeric (2R,3R), (2R,3S), (2S,3R) and (2S,3S)-2-aryl-1-substituted butan-2,3-diols from the derivatives of lactic acid.

Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl

A high purity triazole is obtained by the reaction of a hydrazide of the general formula II and glyoxal followed by the treatment of the intermediate of general formula IV with ammonia. The total process is done in one pot and does not require the isolation of the intermediate IV. The triazole (I) is isolated by distillation. Synthesis of various N.sub.1 -substituted triazoles is also described following the same procedure.

Effective process for the production of 1,2,3-triazoles

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Edmonton, Canada

Bhupinder Palak