Medicis Pharmaceutical Corporation

Prugen IP Holdings, Inc.

Medicis Pharmaceutical Coropration

Bhiku G Patel

Mitchell S Wortzman

Kuljit S Bhatia

Eugene H Gans

R Todd Plott

Philip J Gordon

Mohan Vishnupad

Robert L Knechtel

A composition for increasing the bioavailability of an active pharmaceutical ingredient ('API') in humans and animals, comprising a first water soluble surfactant having a cloud point greater than about 37&#xb0; C., a second water soluble surfactant having a cloud point greater than about 37&#xb0; C., wherein a mixture of the first surfactant and the second surfactant comprises a cloud point less than about 37&#xb0; C.

Bioavailability enhancement delivery composition

A composition for increasing the bioavailability of a statin active pharmaceutical ingredient ('API') in humans and animals, wherein that composition includes a statin API selected from the group consisting of atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin, a first water soluble surfactant having a cloud point greater than about 37&#xb0; C., a second water soluble surfactant having a cloud point greater than about 37&#xb0; C., wherein a mixture of the first surfactant and the second surfactant comprises a cloud point less than about 37&#xb0; C.

Statin bioavailability enhancement delivery composition

A keratolytic emollient, which includes urea, mineral oil, and paraffin wax.

Keratolytic emollient

A composition for increasing the bioavailability of oregano essential oil in humans and animals comprising mixing a first emulsifier and a second emulsifier in a ratio ranging from about 1:1 to about 3:1 with a consumable oil wherein the first emulsifier is polyoxyethylene sorbitan monooleate and the second emulsifier is tocopheryl polyethylene glycol succinate. Adding to that a second mixture of oregano essential oil and the first emulsifier in a ratio of 1:1.

Enhanced absorption of oregano derived oils

A composition for increasing the bioavailability of Acetaminophen in humans and animals, comprising Acetaminophen, a first water soluble surfactant having a cloud point greater than about 37&#xb0; C., a second water soluble surfactant having a cloud point greater than about 37&#xb0; C., wherein a mixture of the first surfactant and the second surfactant comprises a cloud point less than about 37&#xb0; C.

Solubilization and bioavailability of acetaminophen

Minocycline oral dosage forms containing a controlled release carrier are useful for the treatment of acne.

Minocycline oral dosage forms for the treatment of acne

A method for treatment of acne with tetracyclines is provided. A lower sustained dose and no loading dose is employed, with an optional once-a-day dosing regimen.

Method for the treatment of acne

The present invention is a delivery system comprising a pad and a liquid composition, comprising an insoluble dermatologically active ingredient with a viscosity that permits substantially uniform absorption of the composition onto the pad, and the pad is in then packaged in a sealed container.

Delivery system for topical medications

The present invention relates to a composition comprising two or more anti-irritants, each having at least about 7.2% oxygen content. In a separate embodiment, the composition may be defined to include a skin conditioning agent, a skin protectant agent, and an anti-irritant agent, each having an oxygen content of at least about 7.2%. The invention further comprises methods of treating and preventing skin conditions by applying the composition to the skin, and then optionally washing the skin.

Triple anti-irritant composition

The present invention is a composition, preferably a cleanser, comprising sulfur, sodium sulfacetamide and at least one emulsifier with a low HLB number. These compositions are stable and may include moisturizers and humectants. Use of these compositions include treatments for acne rosacea, acne vulgaris and other skin disorders.

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Chandler, AZ, United States of America

Bhiku G Patel