Sun Pharma Advanced Research Company Limited

Bioprojet

Bhavesh Mohanbhai Panchal

Jayraj Dilipbhai Aradhye

Ranjan Kumar Pal

Trinadha Rao Chitturi

Biswajit Samanta

Japan Nitinkumar Desai

Sandeep Pankajbhai Pathak

Jean-Charles Schwartz

Jeanne-Marie Lecomte

Rajamannar Thennati

Marc Capet

Philippe Robert

Isabelle Berrebi-Bertrand

Indraneel Ghosh

Muthukumaran Natarajan Pillai

Amit Pravinbhai Sedani

Kaushikkumar Dhanjibhai Prajapati

Dijixa Pinakin Rana

Nicolas Levoin

Sandeep Pankajkumar Pathak

Kaushik Dhanjibhai Prajapati

Dijixa Chandubhai Rana

Kaushik Dhanjubhai Prajapati

Jignesh Kantilal Jivani

Rajan Kumar Pal

Ranjan Kumar c/o Sun Pharma Advanced Research Centre Pal

Biswajit c/o Sun Pharma Advanced Research Centre Samanta

Rajamannar c/o Sun Pharma Advanced Research Centre Thennati

The present invention provides novel heterocyclic compounds as anticancer agents, especially as estrogen receptor (ER) antagonists/degraders and process for their preparation.

Heterocyclic antiestrogens

A selective estrogen receptor degrader (SERD), a compound 3-(3,5-difluorophenyl)-2-[4-[(E)-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2H-chromen-7-ol, and its S enantiomer, (2S)-3-(3,5-difluorophenyl)-2-[4-[(E)-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2H-chromen-7-ol, or pharmaceutically acceptable salts thereof. Also provided are processes for their preparation. Also provided for is the use of these compounds for the treatment of diseases which are related to modulation of estrogen receptors, such as ER-positive breast cancer.

Selective estrogen receptor degrader

The present invention relates to novel compounds acting as agonists at S1P (sphingosine-1-phosphate) receptors, compositions containing these compounds, use of these compounds in medicine and their process of preparation. 

Piperidinyl monocarboxylic acids as S1P1 receptor agonists

The present invention relates to new compounds of formula (I) possessing agonistic activity at sphingosine-1-phosphate (S1P) receptors, their process of preparation and their use as immunosuppressive agents. The invention is also directed to pharmaceutical compositions containing these compounds and use of these compounds for treatment/prevention of immune mediated diseases and conditions or inflammatory diseases and conditions.

Dicarboxylic acid derivatives as S1P1 receptor agonists

Growing community of inventors

Baroda, India

Bhavesh Mohanbhai Panchal