Lupin, Inc.

Advinus Therapeutics Private Limited

Impetis Biosciences Limited

Bhavesh Dave

Venkata Poornapragnacharyulu Palle

Rajender Kumar Kamboj

Samiron Phukan

Rakesh Kumar Banerjee

Abhijit Datta Khoje

Rajkumar Hangarge

Jitendra Sambhaji Jadhav

Debnath Bhuniya

Kasim A Mookhtiar

Siddhartha De

Gobind Sing Kapkoti

Sujay Basu

Sandeep Bhausaheb Bhosale

Keshav Naik

Santosh Kurhade

Anil M Deshpande

Balasaheb Kobal

Sachin Kandalkar

Anita Chugh

Anil Deshpande

Debanath Bhuniya

Gobind S Kapkoti

Siddartha De

The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment. The compounds as disclosed herein are of Formula (I) below: 

Heterocyclyl compounds as MEK inhibitors

The present invention is related to heteroaryl compounds as MEK inhibitors. The invention includes heteroaryl compounds of formula I, their tautomers and pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present invention also includes process of preparation of the said compounds and intended use in therapy of them. 

Heterocyclyl compounds

Compounds of the present disclosure are 2,2,2-tri-substituted acetamide derivatives of formula (I), its polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, useful as Glucokinase activator. 

2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application

Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed.  The disclosure also provides process of preparation of these acetamide derivatives.

Acetamide derivatives as glucokinase activators, their process and medicinal application

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Pune, India

Bhavesh Dave