Astrazeneca Ab

Bharti Patel

Jeremy Stephen Parker

Michael Butters

Philip Cornwall

Philip Hopes

Jeffrey Norman Crabb

Melvyn Edward Giles

Matthew James Welham

David Simon Ennis

Jacob Robert James Perkins

Phillip Anthony Hopes

Shelly Louise Jenkin

A process for preparing pharmaceutically active compounds of formula (I) or a salt thereof wherein R, n, m, R, R, X, X, Xand Xare as defined in the specification, is described. Novel intermediates are also described and claimed.

Chemical process 632

A process for making a compound of formula (I), which is useful as an intermediate to compounds which activate glucokinase, is described, (wherein P, Rand Rare as defined in the description).

Chemical process for the preparation of an amido-phenoxybenzoic acid compound

 A process for making a compound of formula (I), said process comprising a) reacting a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of Xand ii) a compound of formula (IV) for example by nucleophilic aromatic substitution b) where necessary, converting Xto a carboxylic acid; and c) coupling of the carboxylic acid group to an appropriate heterocyclic amine; wherein all variables are as defined in the description.

Process for making phenoxy benzamide compounds

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Bharti Patel