Agency for Science, Technology and Research

Bhanu Prakash K N

Wieslaw Lucjan Nowinski

Ihar Volkau

Varsha Gupta

Ting Ting Ng

In a method of registering three-dimensional brain images, a reference slice for a midsagittal plane of each image is constructed. The reference slice comprises image points forming a cortical edge. Edge points are selected from these image points such that an ellipse fit to the edge points approximates the cortical edge. The reference ellipse in each image that fits the edge points is determined. The images are registered in a same coordinate system such that the reference ellipses in the images are aligned with one another.

Registering brain images by aligning reference ellipses

Volumes of interest may be defined, within a three-dimensional brain image, for each of three orthogonal directions. Measures, which may, for example, be energy or entropy measures, are determined for slices of the volumes of interest in the three directions. The volume of interest corresponding to the sagittal direction is then identified. The slice, among the slices in the volume of interest corresponding to the identified sagittal direction, having the optical measure is used to define a first estimate of the mid-sagittal plane. The first estimate of the mid-sagittal plane may then be used to build an input to an optimization technique, which operates until a convergence criterion is satisfied, at which point a final estimate of the mid-sagittal plane may be produced. 

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Singapore, Singapore

Bhanu Prakash K N