Ndsu-research Foundation

Becton Dickinson and Company Limited

City University of New York

Bhanu P S Chauhan

Philip R Boudjouk

Thomas E Ready

Andrew B Auerbach

M Ishaq Haider

Richard P Clarke

Shane Jeremy Stafslien

Umar Latif

The present invention provides multi-arm siloxane-based molecules suitable for use as a drug delivery vehicle comprising a central core molecule that comprises a cyclic or cubic siloxane, and a plurality of arms attached to the central core molecule, wherein each arm comprises an organic moiety. The multi-arm siloxane-based molecules described herein are suitable for encapsulation of a therapeutic agent. The invention further includes pharmaceutical compositions comprising the claimed multi-arm siloxane-based molecules and an encapsulated therapeutic agent in combination with a pharmaceutically acceptable carrier. Methods of making and using the multi-arm siloxane-based molecules are also provided.

Multi-arm cyclic or cubic siloxane-based formulations for drug delivery

Polyaminofunctional alkoxy polysiloxanes which exhibit antineoplastic activity are disclosed. Pharmaceutical compositions including an effective amount of a polyaminofunctional alkoxy polysiloxane and/or a pharmaceutically acceptable salt thereof are also disclosed. The application also describes methods of suppressing the growth of neoplastic cells and treating neoplastic conditions.

Antineoplastic polyalkoxyalkylsiloxanes and methods of use thereof

A method of preparing a aminofunctional alkoxy polysiloxane is disclosed. The method includes reacting a polyhydrosiloxane with an alcohol reactant containing an aminoalcohol to form the aminofunctional alkoxy polysiloxane. Linear and cyclic aminofunctional alkoxy polysiloxane are also disclosed. A coating composition comprising an aminofunctional alkoxy polysiloxane is also provided.

Method of preparing aminofunctional alkoxy polysiloxanes

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Staten Island, NY, United States of America

Bhanu P S Chauhan