Atrix Laboratories, Inc.

Tolmar Therapeutics, Inc.

Bhagya L Chandrashekar

Richard L Dunn

John Steven Garrett

Harish Ravivarapu

Mingxing Zhou

Eileen M Jarr

Kathleen A McEnery

The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.

Polymeric delivery formulations of leuprolide with improved efficacy

The invention provides a controlled release polymeric composition which includes a base polymer or copolymer, an organic solvent, a polymeric controlled release additive, and a biologically active agent. The polymeric controlled release additive reduces the initial burst of biologically active agent released from the polymeric composition as it is solidifying to form the solid implant. The controlled release additive is preferably a poly(lactide-co-glycolide)/polyethylene glycol block copolymer.

Controlled release liquid delivery compositions with low initial drug burst

The invention provides an implant composition for sustained delivery of a biologically active agent. The implant composition includes a biologically active agent, a thermoplastic polymer, an organic liquid and a small amount of an aqueous medium. The thermoplastic polymer is insoluble in water so that the implant composition has the form of a substantially homogeneous pliable, moldable solid.

Moldable solid delivery system

Controlled release liquid delivery compositions with low initial drug

Growing community of inventors

Fort Collins, CO, United States of America

Bhagya L Chandrashekar