Galapagos Nv

Abbvie S.a.r.l.

Onco3r Therapeutics Bv

Abbvie Overseas Sarl

Béranger Duthion

Nicolas Desroy

Luke Jonathan Alvey

Philip R Kym

Xueqing Wang

Gregory A Gfesser

Christopher Gaëtan Housseman

Elsa De Lemos

Marlon D Cowart

Jianguo Ji

Christel Jeanne Marie Menet

Steven Emiel Van Der Plas

Sachin V Patel

Jean-Michel Lefrancois

Xavier Marie Bock

Oscar Mammoliti

Romain Luc Marie Gosmini

Gregory John Robert Newsome

Anurupa Shrestha

Pieter Isabelle Roger Claes

Rhalid Akkari

Adeline Marie Elise Palisse

Elizabeth C Swift

Koen Karel Jansen

Brian S Brown

Nuria Merayo Merayo

Christophe Peixoto

Hélène Marie Jary

Florence Marie-Emilie Bonnaterre

Ann De Blieck

Amynata Tirera

Taoues Temal-laïb

Denis Bucher

Matthieu Rafaël Pizzonero

Mathieu Rafaël Pizzonero

Denis Maurice Annoot

Robert J Altenbach

John R Koenig

Ming Clinton Yeung

Bo Liu

Marc J Scanio

Xenia Beebe Searle

Andrew Bogdan

Gang Zhao

Stephen N Greszler

Franck Laurent Brebion

Sylvain Couty

Giovanni Alessandro Tricarico

Chris Tse

Katja Conrath

Tom Roger Lisette De Munck

Brigitte Allart

Caroline Martine Andrée Marie Joannesse

Douglas Cyr

Gert Jules Hector De Wilde

Sandy El Bkassiny

Alexis Patrick Claude Jaunet

Chris Ronan Laruelle

Cornel Catana

The present invention discloses compounds according to Formula I: wherein R, R, R, R, W, W, X, X, X, Y, and Z are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, autoinflammatory diseases, autoimmune diseases, proliferative diseases, fibrotic diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation, diseases involving impairment of bone turnover, diseases associated with hypersecretion of IL-6, diseases associated with hypersecretion of TNFα, interferons, IL-12 and/or IL-23, respiratory diseases, endocrine and/or metabolic diseases, cardiovascular diseases, dermatological diseases, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.

Benzamide-substituted bicyclic imidazo- and pyrazolo-fused -pyridine, -pyrimide, and -pyridazine compounds for treatment of inflammatory diseases

The present invention discloses compounds according to Formula I: wherein R, R, R, R, X, Y, Y, Y, and Z are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, autoinflammatory diseases, autoimmune diseases, proliferative diseases, fibrotic diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation, diseases involving impairment of bone turnover, diseases associated with hypersecretion of TNFα, interferons, IL-6, IL-12 and/or IL-23, respiratory diseases, endocrine and/or metabolic diseases, cardiovascular diseases, dermatological diseases, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.

Compounds and pharmaceutical compositions thereof for the treatment of diseases

The present invention discloses compounds according to Formula I: wherein R, R, R, R, X, Y, Y, Y, and Z are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, autoinflammatory diseases, autoimmune diseases, proliferative diseases, fibrotic diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation, diseases involving impairment of bone turnover, diseases associated with hypersecretion of TNF&#x3b1;, interferons, IL-6, IL-12 and/or IL-23, respiratory diseases, endocrine and/or metabolic diseases, cardiovascular diseases, dermatological diseases, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.

The present invention provides for compounds of formula (I) wherein R, R, R, R, R, and Rhave any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sj&#xf6;gren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

N-sulfonylated-pyrazolo[3,4-b]pyridin-6-carboxamides and method of use

N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use

A corrector agent capable of stabilizing a newly synthesized cystic fibrosis transmembrane conductance regulator (CFTR) protein, useful in the treatment of cystic fibrosis.

Compounds for treatment of cystic fibrosis

The invention discloses compounds of Formula (I) wherein R, R, R, R, R, R, R, and Rare as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

Substituted pyrrolidines and methods of use

The present invention provides for compounds of formula (I) wherein R, R, R, and Rhave any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sj&#xf6;gren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

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Paris, France

Béranger Duthion