Tetracore, Inc.

Beverly Lynn Mangold

Jennifer L Aldrich

William M Nelson

Thomas W O'Brien

The invention relates to aspore specific antigen. Compositions and methods relating to the antigen are provided along with antibodies against the antigen. The antigen is specific forspores relative to the vegetative form of the cells. The antigen is detectable on ungerminated spores. The antibodies may be used to detect the presence ofspores by use of methods provided herein. The invention also relates to articles of manufacture as well as kits comprising the antibodies which may be used in the detection methods of the invention.

Spore specific antigen

The invention relates to spore specific antibodies. Compositions and methods relating to the antibodies are provided along with the hybridomas that produce the antibodies. The antibodies are specific for the spores ofrelative to the vegetative form of the cells. The antibodies are also specific for the spores relative to otherspores and cells. The antibodies may be used to detect the presence ofspores by use of methods provided herein. The invention also relates to articles of manufacture as well as kits comprising these antibodies which may be used in the detection methods of the invention.

Spore specific antibodies

The present invention is directed to diagnostic tools and therapies using antibodies toSpecifically, the present invention is directed to a-specific monoclonal antibody that binds to the EA1 antigen (corresponding to the eag gene) of the S-layer (surface layer) of spores. This monoclonal antibody may be used in a variety of applications, including to specifically detect and diagnosePreferably, antibodies are monoclonal and bind to a surface protein, such as EA1 protein, on the spores ofand not to spores of eitherorAntibodies can be incorporated into detection kits using, for example, colloidal particle based lateral flow detection system. Such detection kits can distinguish anthrax spores from non-pathogenic varieties of spores. In addition, the invention is directed toEA1 antigen and pharmaceuticals such as vaccines that can be used as therapeutics and to develop improved antibodies and detection methods.

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Rockville, MD, United States of America

Beverly Lynn Mangold