Allergan, Inc.

University of Medicine and Dentistry of New Jersey

Beverly E Barton

Arlene E Gwon

William H Garner

Craig E Crosson

Robert J Donnelly

Dimitrios Barlos

Sheraz Riaz

H Dan Lewis

Ali Husain

Disclosed herein are novel glutamate-enhanced cell-penetrating peptides (CPPs) for use as delivery vehicles to mediate intracellular uptake of therapeutic payloads and methods of using the same.

Glutamate-enhanced cell-penetrating peptides and methods of using same

Disclosed is a composition for preventing secondary cataract formation in the eye following removal of the lens, comprising an antibody specific to particular lens cells related to secondary cataract formation, which antibody is conjugated to an antiproliferative agent. The particularly preferred antiproliferative agents require activation after binding of the antibody to the target cells, and activation may be accomplished by addition of a second composition or by exposure of the eye to electromagnetic energy. Also disclosed is a method of using the composition by administering it directly to the site from which the lens was removed to kill or prevent proliferation of lens cells.

Prevention of lens-related tissue growth in the eye

Growing community of inventors

West Orange, NJ, United States of America

Beverly E Barton