Dana-farber-cancer Institute Inc.

Biopure Corporation

Other

Avicena Group, Inc.

Amira, Inc.

Beverly A Teicher

Carl W Rausch

Rima Kaddurah-Daouk

Robert E Hopkins, 2nd

Donald W Kufe

Howard J Halpern

Robert E Hopkins, Ii

Zhen-Dong Huang

The present invention relates to the use of creatine compounds including cyclocreatine and creatine phosphate for treating or preventing a metabolic disorder consisting of hyperglycemia, insulin dependent diabetes mellitus, impaired glucose tolerance, hyperinsulinemia, insulin insensitivity, diabetes related diseases in a patient experiencing said disorder. The creatine compounds which can be used in the present method include (1) analogues of creatine which can act as substrates or substrate analogues for the enzyme creatine kinase; (2) compounds which can act as activators or inhibitors of creatine kinase; (3) compounds which can modulate the creatine transporter (4) N-phosphocreatine analogues bearing transferable or non-transferable moieties which mimic the N-phosphoryl group. (5) compounds which modify the association of creatine kinase with other cellular components.

Use of creatine analogues and creatine kinase modulators for the

A method of increasing the effective life of oxygen-delivery agents is described. The method involves administering an oxygen-enriched atmosphere to a subject that has received the oxygen-delivery agent at a predetermined time.

Method of enhancing the effective life of oxygen-delivery agents

A method is disclosed treating a tumor in a host by administering a nonemulsified ultrapurified polymerized hemoglobin solution to the host and also administering a chemotherapeutic agent to the host. In a particularly preferred embodiment, the hemoglobin is bovine hemoglobin.

Method for treating a tumor with a chemotherapeutic agent

The present invention provides for the use of creatine compounds and hyperplastic inhibitory agents for prophylactic and/or therapeutic treatments of undesirable cell growth, e.g. tumors. The present invention provides methods of using creatine compounds, in combination with a hyperplastic inhibitory agent, to inhibit the growth of undesirable cells in a subject. The present invention is based, at least in part, on the discovery that creatine compounds and hyperplastic inhibitory agents, such as inhibitory agents, additively and synergistically combine to inhibit cell growth. The present invention further pertains to compositions for inhibiting undesirable cell growth in a subject. The compositions of the present invention include an effective amount of the creatine compound and a hyperplastic inhibitory agent in a pharmaceutically acceptable carrier. Other aspects of the invention include packaged creatine compounds and inhibitory agents. The packaged compounds and agents also include instructions for using the creatine compound/inhibitory agent combination for inhibiting undesirable cell growth in a patient or instructions for using the compounds and agents, in selected quantities, in a pharmaceutically acceptable carrier.

Methods of inhibiting undesirable cell growth using a combination of a

The present invention relates to 1,2-benzoquinones; methods of preparation of 1,2-benzoquinones that include preparation of 4,5-substituted-1,2-benzoquinones in a one-pot reaction; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such benzoquinones.

1,2-benzoquinones and methods for making and using same

Selective isotopic-labeling of spin label compounds, used in electron spin resonance spectroscopy to detect, measure and monitor the presence of paramagnetic species, increases the sensitivity of the electron spin resonance technique in assays for paramagnetic species, such as the determination of oxygen tension in solution or in a biological sample, like a living organism. Spin label compounds, such as nitroxides, like 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrroline-1-yloxyl (CTPO), are selectively, but not completely, isotopically-labeled, such as partially deuterated, to increase the sensitivity and reliability of assays employing electron spin resonance spectroscopic measurements.

Selective isotopic labeling of spin labels for electron spin resonance

A method is disclosed treating a tumor in a host by administering an ultrapurified polymerized hemoglobin solution to the host and thereafter administering ionizing radiation, such as X-rays, to the tumor. In a particularly preferred embodiment, the hemoglobin is bovine hemoglobin.

Method for treating a tumor with ionizing radiation

Complexes having the structure ##STR1## in which R, R.sub.1, R.sub.2, R.sub.3 represent lower alkyl groups are cytotoxic to tumor cells in mammals and enhance the killing effect of radiation and heat.

Growing community of inventors

Needham, MA, United States of America

Beverly A Teicher