Prometic Biotherapeutics, Inc.

The Rockefeller University

Tibotec Pharmaceuticals Ltd.

Aaron Diamond Aids Research Center

Kedrion Biopharma Inc.

Betty Yu

Martin Robitaille

Stacy Plum

Davida Blackman

William Garzon-Rodriguez

John W Erickson

Sergei V Gulnik

Martin Markowitz

Pharmaceutical compositions comprising plasminogen or a biologically active variant thereof are disclosed. In an embodiment, the composition comprises a tonicity modifier, a bulking agent, and a stabilising agent and has a pH of about 3.0 to about 10.0. In another embodiment, the composition contains an amount of particles in suspension equal to or greater than 10 &#x3bc;m which is lower than 6000 particles per 100 ml, and preferably lower than 2000 particles per 100 ml. Uses of these compositions as a medicament is contemplated. Various therapeutic uses of these pharmaceutical compositions is also contemplated.

Pharmaceutical composition comprising plasminogen and uses thereof

Pharmaceutical compositions comprising plasminogen or a biologically active variant thereof are disclosed. In an embodiment, the composition comprises a tonicity modifier, a bulking agent, and a stabilizing agent and has a pH of about 3.0 to about 10.0. In another embodiment, the composition contains an amount of particles in suspension equal to or greater than 10 &#x3bc;m which is lower than 6000 particles per 100 ml, and preferably lower than 2000 particles per 100 ml. Uses of these compositions as a medicament is contemplated. Various therapeutic uses of these pharmaceutical compositions is also contemplated.

The present invention concerns a further development and use of biological assays to determine the amount or concentration of an active ingredient present in a sample. The enzyme assay of the present invention determines the amount or concentration of protease inhibitors, including retroviral protease inhibitors such as HIV inhibitors.

Protease assay for therapeutic drug monitoring

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Frederick, MD, United States of America

Betty Yu