Takeda Pharmaceutical Company Limited

Vividion Therapeutics, Inc.

Takeda Pharmaceutical Company Limied

Betty Lam

Holger Monenschein

Holly Reichard

Stephen A Hitchcock

Zhe Nie

Benjamin Jones

Victoria Feher

Qing Dong

Zhiyuan Zhang

Christopher Ronald Smith

Shota Kikuchi

Yasuyoshi Arikawa

Masashi Takahashi

Stephen L Gwaltney

Jason W Brown

Huikai Sun

Maria Hopkins

Mark E Adams

Jeffrey Alan Stafford

Jun Feng

Stephen W Kaldor

Zhe Li

David S Weinstein

Sheldon Cao

Andre A Kiryanov

Mitsunori Kono

Yan Liu

Srinivasa Reddy Natala

Sean Timothy Murphy

Lily Kwok

Melinda Davis

Jason Green

Takashi Ichikawa

Rongliang Chen

Benjamin Horning

Scott Olsen

Srinivasa Ready Natala

Zachary Owyang

Robert Malmstrom

Kelsey Lamb

Don Rogness

Larry Burgess

Natasha O'rourke

Chrisopher McBride

Steven James Wilkens

Matthew Lardy

Christopher Mcbride

Sheldon X Cao

Christopher Smith

Stephan Hitchcock

Disclosed are compounds of Formula (1) and pharmaceutically acceptable salts thereof, wherein α, β, n, R, R, R, R, R, R, R, X, X, Xand Xare defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula (1), to pharmaceutical compositions comprising them, and to their use for treating diseases, disorders, and conditions associated with GPR139.

Azole-fused pyridazin-3(2H)-one derivatives

Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R, R, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Pharmaceutical compositions comprising WRN helicase inhibitors

The present invention provides a method for treating a disease, disorder or condition associated with GPR139 using compounds of formula 1: which are agonists of GPR139, certain compounds encompassed by formula 1, pharmaceutical compositions thereof, processes for making the compounds, and intermediates thereof.

4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139

The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.

Pyrazines as modulators of GPR6

4-OXO-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139

4-OXO-3,4-dihydro-1,2,3-benzotriazine as modulators of GPR139

Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, L, L, R, R, R, and Rare defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, pharmaceutical compositions containing them, and their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other disorders, diseases, and conditions for which inhibition of SYK is indicated.

Fused heteroaromatic pyrrolidinones as SYK inhibitors

Fused heteroaromatic pyrrolidinones

Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Polo-like kinase inhibitors

Disclosed are compounds, pharmaceutical compositions, kits, articles of manufacture, methods of using, and methods of preparing compounds having the formula: wherein the variables are as defined herein. The disclosed compounds are inhibitors of Renin.

Renin inhibitors

The invention provides compounds, pharmaceutical compositions, kits, method of preparing, and method of using the compounds which exhibit renin and other S9 proteases activities and consist of the formula:&#x2014;wherein the variables are as defined herein. 

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San Diego, CA, United States of America

Betty Lam